TY - JOUR
T1 - Polymorphisms of the prion protein gene (PRNP) in a Serbian population
AU - Dimitrijević, Rajna
AU - Čadež, Ivana
AU - Keckarević-Marković, Milica
AU - Keckarević, Dušan
AU - Kecmanović, Miljana
AU - Dobričić, Valerija
AU - Savić-Pavićević, Dušanka
AU - Brajušković, Goran
AU - Romac, Stanka
PY - 2010/5
Y1 - 2010/5
N2 - Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
AB - Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
UR - http://www.scopus.com/inward/record.url?scp=77954180773&partnerID=8YFLogxK
U2 - 10.3109/00207451003765907
DO - 10.3109/00207451003765907
M3 - Journal articles
C2 - 20583902
AN - SCOPUS:77954180773
SN - 0020-7454
VL - 120
SP - 496
EP - 501
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 7
ER -
