Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants

J. Spiegler*, A. Gilhaus, I. R. König, E. Kattner, M. Vochem, H. Küster, J. Möller, D. Müller, A. Kribs, H. Segerer, C. Wieg, W. Nikischin, A. Von Der Wense, C. Gebauer, E. Herting, W. Göpel

*Korrespondierende/r Autor/-in für diese Arbeit
19 Zitate (Scopus)

Abstract

Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.

OriginalspracheEnglisch
ZeitschriftNeonatology
Jahrgang97
Ausgabenummer1
Seiten (von - bis)10-14
Seitenumfang5
ISSN1661-7800
DOIs
PublikationsstatusVeröffentlicht - 01.2009

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  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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