Plasma metabolic profile in COPD patients: Effects of exercise and endurance training

Diego A. Rodríguez; Gema Alcarraz-Vizán; Santiago Díaz-Moralli; Michelle A.C. Reed; Federico P. Gómez; Francesco Falciani; Ulrich Günther; Josep Roca; Marta Cascante

doi:10.1007/s11306-011-0336-x

Plasma metabolic profile in COPD patients: Effects of exercise and endurance training

Diego A. Rodríguez, Gema Alcarraz-Vizán, Santiago Díaz-Moralli, Michelle A.C. Reed, Federico P. Gómez, Francesco Falciani, Ulrich Günther, Josep Roca^*, Marta Cascante

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Chemie und Metabolomics

33 Zitate (Scopus)

Abstract

The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenergetics in COPD. The study aims to test this hypothesis by evaluating plasma metabolic profiles in COPD patients before and after 8 weeks of endurance exercise training. We studied blood samples from 18 COPD patients and 12 healthy subjects. Pre- and post-training blood plasma samples at rest and after constant-work rate exercise (CWRE) at 70% of pre-training Watts peak were analyzed by ¹H-nuclear magnetic resonance spectroscopy to assess metabolite profiles. The two groups presented training-induced physiological changes in the VO ₂ peak and in blood lactate levels (P < 0.01 each). Before training, the two groups also showed differences in metabolic profiles at rest (P < 0.05). Levels of valine (r = 0. 51, P < 0.01), alanine (r = 0. 45, P < 0.05) and isoleucine (r = 0. 51, P < 0.01) were positively associated with body composition (Fat Free Mass Index). While training showed a significant impact on the metabolic profile in healthy subjects (P < 0.001), with changes in levels of amino acids, creatine, succinate, pyruvate, glucose and lactate (P < 0.05 each), no equivalent training-induced effects were seen in COPD patients in whom only lactate decreased (P < 0.05). This study shows that plasma metabolic profiling contributes to the phenotypic characterization of COPD patients.

Originalsprache	Englisch
Zeitschrift	Metabolomics
Jahrgang	8
Ausgabenummer	3
Seiten (von - bis)	508-516
Seitenumfang	9
ISSN	1573-3882
DOIs	https://doi.org/10.1007/s11306-011-0336-x
Publikationsstatus	Veröffentlicht - 06.2012

Fördermittel

Acknowledgments The authors thank the contribution of Elena Gimeno, Jordi Vilaro, Phillip Muñoz, Yolanda Torralba and all the technical staff of the Lung Function Laboratory for their collaboration in the physiological studies and during the training program. This study was supported by European Commission (FP6) BIOBRIDGE (LSHG-CT-2006-037939.); Fundació Marató TV3-042010 Fondo de Investigaciones Sanitarias (FIS-PI061510); CIBERES (CB-06/06), ISCIII-RTICC (RD06/0020/0046); Comissionat per a Universitats i Recerca de la Generalitat de Catalunya (2009SGR1308 and 2009SGR911), and Icrea Academia award 2010 granted to M. Cascante, and Spanish Government Ministry of Science and Innovation and the European Union FEDER funds (SAF2008-00164). Financial support was also given by the Access to Research Infrastructures activity in the 6th Framework Program of the EC (Contract# RII3-026145, EU-NMR) for obtaining NMR spectra at HWB-NMR.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1007/s11306-011-0336-x

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title = "Plasma metabolic profile in COPD patients: Effects of exercise and endurance training",

abstract = "The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenergetics in COPD. The study aims to test this hypothesis by evaluating plasma metabolic profiles in COPD patients before and after 8 weeks of endurance exercise training. We studied blood samples from 18 COPD patients and 12 healthy subjects. Pre- and post-training blood plasma samples at rest and after constant-work rate exercise (CWRE) at 70\% of pre-training Watts peak were analyzed by 1H-nuclear magnetic resonance spectroscopy to assess metabolite profiles. The two groups presented training-induced physiological changes in the VO 2 peak and in blood lactate levels (P < 0.01 each). Before training, the two groups also showed differences in metabolic profiles at rest (P < 0.05). Levels of valine (r = 0. 51, P < 0.01), alanine (r = 0. 45, P < 0.05) and isoleucine (r = 0. 51, P < 0.01) were positively associated with body composition (Fat Free Mass Index). While training showed a significant impact on the metabolic profile in healthy subjects (P < 0.001), with changes in levels of amino acids, creatine, succinate, pyruvate, glucose and lactate (P < 0.05 each), no equivalent training-induced effects were seen in COPD patients in whom only lactate decreased (P < 0.05). This study shows that plasma metabolic profiling contributes to the phenotypic characterization of COPD patients.",

author = "Rodr{\'i}guez, \{Diego A.\} and Gema Alcarraz-Viz{\'a}n and Santiago D{\'i}az-Moralli and Reed, \{Michelle A.C.\} and G{\'o}mez, \{Federico P.\} and Francesco Falciani and Ulrich G{\"u}nther and Josep Roca and Marta Cascante",

note = "Funding Information: Acknowledgments The authors thank the contribution of Elena Gimeno, Jordi Vilaro, Phillip Mu{\~n}oz, Yolanda Torralba and all the technical staff of the Lung Function Laboratory for their collaboration in the physiological studies and during the training program. This study was supported by European Commission (FP6) BIOBRIDGE (LSHG-CT-2006-037939.); Fundaci{\'o} Marat{\'o} TV3-042010 Fondo de Investigaciones Sanitarias (FIS-PI061510); CIBERES (CB-06/06), Funding Information: ISCIII-RTICC (RD06/0020/0046); Comissionat per a Universitats i Recerca de la Generalitat de Catalunya (2009SGR1308 and 2009SGR911), and Icrea Academia award 2010 granted to M. Cascante, and Spanish Government Ministry of Science and Innovation and the European Union FEDER funds (SAF2008-00164). Financial support was also given by the Access to Research Infrastructures activity in the 6th Framework Program of the EC (Contract\# RII3-026145, EU-NMR) for obtaining NMR spectra at HWB-NMR. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2012",

month = jun,

doi = "10.1007/s11306-011-0336-x",

language = "English",

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pages = "508--516",

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AU - Rodríguez, Diego A.

AU - Alcarraz-Vizán, Gema

AU - Díaz-Moralli, Santiago

AU - Reed, Michelle A.C.

AU - Gómez, Federico P.

AU - Falciani, Francesco

AU - Günther, Ulrich

AU - Roca, Josep

AU - Cascante, Marta

N1 - Funding Information: Acknowledgments The authors thank the contribution of Elena Gimeno, Jordi Vilaro, Phillip Muñoz, Yolanda Torralba and all the technical staff of the Lung Function Laboratory for their collaboration in the physiological studies and during the training program. This study was supported by European Commission (FP6) BIOBRIDGE (LSHG-CT-2006-037939.); Fundació Marató TV3-042010 Fondo de Investigaciones Sanitarias (FIS-PI061510); CIBERES (CB-06/06), Funding Information: ISCIII-RTICC (RD06/0020/0046); Comissionat per a Universitats i Recerca de la Generalitat de Catalunya (2009SGR1308 and 2009SGR911), and Icrea Academia award 2010 granted to M. Cascante, and Spanish Government Ministry of Science and Innovation and the European Union FEDER funds (SAF2008-00164). Financial support was also given by the Access to Research Infrastructures activity in the 6th Framework Program of the EC (Contract# RII3-026145, EU-NMR) for obtaining NMR spectra at HWB-NMR. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/6

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N2 - The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenergetics in COPD. The study aims to test this hypothesis by evaluating plasma metabolic profiles in COPD patients before and after 8 weeks of endurance exercise training. We studied blood samples from 18 COPD patients and 12 healthy subjects. Pre- and post-training blood plasma samples at rest and after constant-work rate exercise (CWRE) at 70% of pre-training Watts peak were analyzed by 1H-nuclear magnetic resonance spectroscopy to assess metabolite profiles. The two groups presented training-induced physiological changes in the VO 2 peak and in blood lactate levels (P < 0.01 each). Before training, the two groups also showed differences in metabolic profiles at rest (P < 0.05). Levels of valine (r = 0. 51, P < 0.01), alanine (r = 0. 45, P < 0.05) and isoleucine (r = 0. 51, P < 0.01) were positively associated with body composition (Fat Free Mass Index). While training showed a significant impact on the metabolic profile in healthy subjects (P < 0.001), with changes in levels of amino acids, creatine, succinate, pyruvate, glucose and lactate (P < 0.05 each), no equivalent training-induced effects were seen in COPD patients in whom only lactate decreased (P < 0.05). This study shows that plasma metabolic profiling contributes to the phenotypic characterization of COPD patients.

AB - The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenergetics in COPD. The study aims to test this hypothesis by evaluating plasma metabolic profiles in COPD patients before and after 8 weeks of endurance exercise training. We studied blood samples from 18 COPD patients and 12 healthy subjects. Pre- and post-training blood plasma samples at rest and after constant-work rate exercise (CWRE) at 70% of pre-training Watts peak were analyzed by 1H-nuclear magnetic resonance spectroscopy to assess metabolite profiles. The two groups presented training-induced physiological changes in the VO 2 peak and in blood lactate levels (P < 0.01 each). Before training, the two groups also showed differences in metabolic profiles at rest (P < 0.05). Levels of valine (r = 0. 51, P < 0.01), alanine (r = 0. 45, P < 0.05) and isoleucine (r = 0. 51, P < 0.01) were positively associated with body composition (Fat Free Mass Index). While training showed a significant impact on the metabolic profile in healthy subjects (P < 0.001), with changes in levels of amino acids, creatine, succinate, pyruvate, glucose and lactate (P < 0.05 each), no equivalent training-induced effects were seen in COPD patients in whom only lactate decreased (P < 0.05). This study shows that plasma metabolic profiling contributes to the phenotypic characterization of COPD patients.

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Plasma metabolic profile in COPD patients: Effects of exercise and endurance training

Abstract

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