Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review

Luca Tagliaferri, Francesco Bussu*, Bruno Fionda, Francesco Catucci, Mario Rigante, Maria Antonietta Gambacorta, Rosa Autorino, Gian Carlo Mattiucci, Francesco Miccichè, Elisa Placidi, Mario Balducci, Jacopo Galli, Gaetano Paludetti, György Kovacs, Vincenzo Valentini

*Korrespondierende/r Autor/-in für diese Arbeit
12 Zitate (Scopus)

Abstract

Aim: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. Materials and methods: Patients treated with prior radiation doses > 65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library. Results: Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review. Conclusions: IMBT could play an important role in the retreatment of recurrent head and neck cancer.

OriginalspracheEnglisch
ZeitschriftTumori
Jahrgang103
Ausgabenummer6
Seiten (von - bis)516-524
Seitenumfang9
ISSN0300-8916
DOIs
PublikationsstatusVeröffentlicht - 03.08.2017

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