Pemphigoid gestationis als erstmanifestation eines mata-stasierenden chorionkarzinoms

A 29-year-old woman developed pruritic urticarial plaques and vesicles 3 months after delivery of a healthy daughter. Two months later pemphigoid gestationis (PG) was diagnosed based on histopathological and immunopathological findings. At the same time elevated serum levels for β-HCG and a large mass in the liver were noted. A liver biopsy confirmed the diagnosis of metastatic choriocarcinoma, which was responsible for the PG metastasis. Upon initiation of chemotherapy, complete healing of the PG was observed within 4 weeks and autoantibodies to BP180NC16A could no longer be identified. In parallel, both a decrease of β-HCG levels and tumor size was observed.