P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh; Rachel Sarig; Elad Bar Natan; Alina Molchadsky; Shalom Madar; Chamutal Bornstein; Yosef Buganim; Tirosh Shapira; Naomi Goldfinger; Ralf Paus; Varda Rotter

doi:10.1016/j.febslet.2010.04.058

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh^*, Rachel Sarig, Elad Bar Natan, Alina Molchadsky, Shalom Madar, Chamutal Bornstein, Yosef Buganim, Tirosh Shapira, Naomi Goldfinger, Ralf Paus, Varda Rotter

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Dermatologie, Allergologie und Venerologie

The Weizmann Institute of Science

45 Zitate (Scopus)

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

Originalsprache	Englisch
Zeitschrift	FEBS Letters
Jahrgang	584
Ausgabenummer	11
Seiten (von - bis)	2473-2477
Seitenumfang	5
ISSN	0014-5793
DOIs	https://doi.org/10.1016/j.febslet.2010.04.058
Publikationsstatus	Veröffentlicht - 01.06.2010

Fördermittel

Supported by a Center of Excellence grant from the Flight Attendant Medical Research Institute. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute. Appendix A

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Dokumente

10.1016/j.febslet.2010.04.058

Weitere Links

Link to publication in Scopus

Zitieren

@article{6f7e141c70604631a789699977a33b6a,

title = "P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss",

abstract = "The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.",

author = "Ran Brosh and Rachel Sarig and Natan, \{Elad Bar\} and Alina Molchadsky and Shalom Madar and Chamutal Bornstein and Yosef Buganim and Tirosh Shapira and Naomi Goldfinger and Ralf Paus and Varda Rotter",

year = "2010",

month = jun,

day = "1",

doi = "10.1016/j.febslet.2010.04.058",

language = "English",

volume = "584",

pages = "2473--2477",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc",

number = "11",

}

TY - JOUR

T1 - P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

AU - Brosh, Ran

AU - Sarig, Rachel

AU - Natan, Elad Bar

AU - Molchadsky, Alina

AU - Madar, Shalom

AU - Bornstein, Chamutal

AU - Buganim, Yosef

AU - Shapira, Tirosh

AU - Goldfinger, Naomi

AU - Paus, Ralf

AU - Rotter, Varda

PY - 2010/6/1

Y1 - 2010/6/1

N2 - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

AB - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

UR - https://www.scopus.com/pages/publications/77952955114

U2 - 10.1016/j.febslet.2010.04.058

DO - 10.1016/j.febslet.2010.04.058

M3 - Journal articles

C2 - 20434500

AN - SCOPUS:77952955114

SN - 0014-5793

VL - 584

SP - 2473

EP - 2477

JO - FEBS Letters

JF - FEBS Letters

IS - 11

ER -

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Abstract

Fördermittel

UN SDGs

Dokumente

Weitere Links

Fingerprint

Zitieren