Orexins (hypocretins) and adrenal function

O. Jöhren*, N. Brüggemann, P. Dominiak

*Korrespondierende/r Autor/-in für diese Arbeit
25 Zitate (Scopus)


The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system. In rat and human adrenal glands, both OX 1 and OX2 receptor subtypes have been described with a predominant expression of OX2 receptors in the adrenal cortex. In male rats, adrenocortical OX2 receptors are much higher expressed than in female rats. Various experimental data demonstrate a stimulatory effect of orexins on the secretion of adrenocortical steroids, mainly on glucocorticoids. Some results also suggest the regulation of catecholamine synthesis and release by orexins. Whether the gender-dependent expression of adrenocortical OX2 receptors has functional correlates awaits future clarification. As plasma orexin appears to rise during hunger and hypoglycemia, orexins may link adrenal functions with energy homeostasis.

ZeitschriftHormone and Metabolic Research
Seiten (von - bis)370-375
PublikationsstatusVeröffentlicht - 01.06.2004


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