TY - JOUR
T1 - Optical coherence tomography provides an optical biopsy of burn wounds in children- A pilot study
AU - Lindert, Judith
AU - Tafazzoli-Lari, Kianusch
AU - Tüshaus, Ludger
AU - Larsen, Beke
AU - Bacia, Anna
AU - Bouteleux, Marie
AU - Adler, Tina
AU - Dalicho, Valerie
AU - Vasileidos, Vasileiadis
AU - Kisch, Tobias
AU - Stang, Felix
AU - Welzel, Julia
AU - Wünsch, Lutz
N1 - Funding Information:
The study was funded by the University of Lübeck. No conflict of interest exists between the Vivosight Dx© company and any of the researchers.
Publisher Copyright:
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Thermic injuries are among the most severe injuries in childhood. Burn depth is the most relevant prognostic factor, and still its assessment is both difficult and controversial. This diagnostic uncertainty results in repeated wound assessments over a 10-day period and carries a relevant risk for over- A nd undertreatment. Precise wound assessment would thus be a significant step toward improved care. Optical coherence tomography (OCT) is a noninvasive laser-based technique with a penetration depth of ∼2 mm. It provides structural images of the skin while dynamic OCT (D-OCT) shows blood vessels. In this study, we investigated burns and scalds in 130 children with OCT and D-OCT to identify patterns of injury related to the depth of the burn wound. OCT and D-OCT images from burned skin differed consistently from normal skin. We observed several not formerly described morphologic patterns associated with burn injuries. Superficial wounds are characterized by a loss of the epidermal layer and a smooth surface. With deeper wounds, surface irregularity, loss of the dermal papillary pattern, disappearance of skin lines, and characteristic changes in the microvascular architecture were observed. This is the first systematic study of D-OCT in the assessment of burn wounds in children. A number of burn-associated patterns of injury were identified. Thus, D-OCT provided an "optical biopsy" of burn wounds that adds significant information about the severity of a burn wound.
AB - Thermic injuries are among the most severe injuries in childhood. Burn depth is the most relevant prognostic factor, and still its assessment is both difficult and controversial. This diagnostic uncertainty results in repeated wound assessments over a 10-day period and carries a relevant risk for over- A nd undertreatment. Precise wound assessment would thus be a significant step toward improved care. Optical coherence tomography (OCT) is a noninvasive laser-based technique with a penetration depth of ∼2 mm. It provides structural images of the skin while dynamic OCT (D-OCT) shows blood vessels. In this study, we investigated burns and scalds in 130 children with OCT and D-OCT to identify patterns of injury related to the depth of the burn wound. OCT and D-OCT images from burned skin differed consistently from normal skin. We observed several not formerly described morphologic patterns associated with burn injuries. Superficial wounds are characterized by a loss of the epidermal layer and a smooth surface. With deeper wounds, surface irregularity, loss of the dermal papillary pattern, disappearance of skin lines, and characteristic changes in the microvascular architecture were observed. This is the first systematic study of D-OCT in the assessment of burn wounds in children. A number of burn-associated patterns of injury were identified. Thus, D-OCT provided an "optical biopsy" of burn wounds that adds significant information about the severity of a burn wound.
UR - http://www.scopus.com/inward/record.url?scp=85054895924&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.23.10.106005
DO - 10.1117/1.JBO.23.10.106005
M3 - Journal articles
C2 - 30324791
AN - SCOPUS:85054895924
SN - 1083-3668
VL - 23
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 10
M1 - 106005
ER -