Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Andreas Ebneter, Ralf Brinkmann, Dirk Theisen-Kunde, Boris Považay, Christoph Meier

Abstract

Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 - 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This "Spectralis Centaurus" system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

OriginalspracheEnglisch
TitelMedical Laser Applications and Laser-Tissue Interactions IX
Redakteure/-innenLothar D. Lilge, Carsten M. Philipp
Seitenumfang6
Band11079
Herausgeber (Verlag)SPIE
Erscheinungsdatum22.07.2019
Aufsatznummer1107903
ISBN (Print)978-151062851-9
DOIs
PublikationsstatusVeröffentlicht - 22.07.2019
VeranstaltungMedical Laser Applications and Laser-Tissue Interactions IX 2019
- Munich, Deutschland
Dauer: 23.06.201924.06.2019

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