Oligomeric nucleic acids as antivirals

Alessandra Mescalchin, Tobias Restle*

*Korrespondierende/r Autor/-in für diese Arbeit
24 Zitate (Scopus)

Abstract

Based on the natural functions and chemical characteristics of nucleic acids, a variety of novel synthetic drugs and tools to explore biological systems have become available in recent years. To date, a great number of antisense oligonucleotides, RNA interference-based tools, CpG-containing oligonucleotides, catalytic oligonucleotides, decoys and aptamers has been produced synthetically and applied successfully for understanding and manipulating biological processes and in clinical trials to treat a variety of diseases. Their versatility and potency make them equally suited candidates for fighting viral infections. Here, we describe the different types of nucleic acid-based antivirals, their mechanism of action, their advantages and limitations, and their future prospects.

OriginalspracheEnglisch
ZeitschriftMolecules
Jahrgang16
Ausgabenummer2
Seiten (von - bis)1271-1296
Seitenumfang26
DOIs
PublikationsstatusVeröffentlicht - 01.02.2011

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