Novel roles of complement in T effector cell regulation

Peter S. Heeger; Claudia Kemper

doi:10.1016/j.imbio.2011.06.004

Novel roles of complement in T effector cell regulation

Peter S. Heeger, Claudia Kemper^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Systemische Entzündungsforschung

Mount Sinai School of Medicine

90 Zitate (Scopus)

Abstract

Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.

Originalsprache	Englisch
Zeitschrift	Immunobiology
Jahrgang	217
Ausgabenummer	2
Seiten (von - bis)	216-224
Seitenumfang	9
ISSN	0171-2985
DOIs	https://doi.org/10.1016/j.imbio.2011.06.004
Publikationsstatus	Veröffentlicht - 02.2012

Fördermittel

Work in the Heeger and Kemper laboratories is supported by the NIH grants R01AI043578 and R01AI071185 awarded to PSH and an MRC Research Grant (Grant no. G1002165 awarded to CK), the Medical Research Council Centre for Transplantation, Guy's Hospital, King's College and the Department of Health, National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's & St. Thomas’ NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust.

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1016/j.imbio.2011.06.004

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title = "Novel roles of complement in T effector cell regulation",

abstract = "Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.",

author = "Heeger, \{Peter S.\} and Claudia Kemper",

note = "Funding Information: Work in the Heeger and Kemper laboratories is supported by the NIH grants R01AI043578 and R01AI071185 awarded to PSH and an MRC Research Grant (Grant no. G1002165 awarded to CK), the Medical Research Council Centre for Transplantation, Guy's Hospital, King's College and the Department of Health, National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's \& St. Thomas{\textquoteright} NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust.",

year = "2012",

month = feb,

doi = "10.1016/j.imbio.2011.06.004",

language = "English",

volume = "217",

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AU - Heeger, Peter S.

AU - Kemper, Claudia

N1 - Funding Information: Work in the Heeger and Kemper laboratories is supported by the NIH grants R01AI043578 and R01AI071185 awarded to PSH and an MRC Research Grant (Grant no. G1002165 awarded to CK), the Medical Research Council Centre for Transplantation, Guy's Hospital, King's College and the Department of Health, National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's & St. Thomas’ NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust.

PY - 2012/2

Y1 - 2012/2

N2 - Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.

AB - Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.

UR - https://www.scopus.com/pages/publications/84855296204

U2 - 10.1016/j.imbio.2011.06.004

DO - 10.1016/j.imbio.2011.06.004

M3 - Scientific review articles

C2 - 21742404

AN - SCOPUS:84855296204

SN - 0171-2985

VL - 217

SP - 216

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JO - Immunobiology

JF - Immunobiology

IS - 2

ER -

Novel roles of complement in T effector cell regulation

Abstract

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