TY - JOUR
T1 - Novel roles of complement in T effector cell regulation
AU - Heeger, Peter S.
AU - Kemper, Claudia
N1 - Funding Information:
Work in the Heeger and Kemper laboratories is supported by the NIH grants R01AI043578 and R01AI071185 awarded to PSH and an MRC Research Grant (Grant no. G1002165 awarded to CK), the Medical Research Council Centre for Transplantation, Guy's Hospital, King's College and the Department of Health, National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's & St. Thomas’ NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust.
PY - 2012/2
Y1 - 2012/2
N2 - Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.
AB - Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.
UR - http://www.scopus.com/inward/record.url?scp=84855296204&partnerID=8YFLogxK
U2 - 10.1016/j.imbio.2011.06.004
DO - 10.1016/j.imbio.2011.06.004
M3 - Scientific review articles
C2 - 21742404
AN - SCOPUS:84855296204
SN - 0171-2985
VL - 217
SP - 216
EP - 224
JO - Immunobiology
JF - Immunobiology
IS - 2
ER -
