Not all psychedelics are created equal

Johannes G. Ramaekers; Pablo Mallaroni; Natasha L. Mason; Mihai Avram

doi:10.1038/s44220-025-00551-y

Not all psychedelics are created equal

Johannes G. Ramaekers^*, Pablo Mallaroni, Natasha L. Mason, Mihai Avram^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Psychiatrie und Psychotherapie

Maastricht University

Abstract

Psychedelics act on multiple receptors beyond 5-HT2A, but their contribution to subjective and behavioral effects is poorly defined. A receptor-informed, neuroimaging-integrated framework can better capture this complexity and guide more-personalized, mechanism-based psychedelic therapies.

Originalsprache	Englisch
Zeitschrift	Nature Mental Health
Jahrgang	3
Ausgabenummer	12
Seiten (von - bis)	1465-1467
Seitenumfang	3
DOIs	https://doi.org/10.1038/s44220-025-00551-y
Publikationsstatus	Veröffentlicht - 12.2025

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10.1038/s44220-025-00551-y

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title = "Not all psychedelics are created equal",

abstract = "Psychedelics act on multiple receptors beyond 5-HT2A, but their contribution to subjective and behavioral effects is poorly defined. A receptor-informed, neuroimaging-integrated framework can better capture this complexity and guide more-personalized, mechanism-based psychedelic therapies.",

author = "Ramaekers, \{Johannes G.\} and Pablo Mallaroni and Mason, \{Natasha L.\} and Mihai Avram",

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year = "2025",

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doi = "10.1038/s44220-025-00551-y",

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AU - Ramaekers, Johannes G.

AU - Mallaroni, Pablo

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N2 - Psychedelics act on multiple receptors beyond 5-HT2A, but their contribution to subjective and behavioral effects is poorly defined. A receptor-informed, neuroimaging-integrated framework can better capture this complexity and guide more-personalized, mechanism-based psychedelic therapies.

AB - Psychedelics act on multiple receptors beyond 5-HT2A, but their contribution to subjective and behavioral effects is poorly defined. A receptor-informed, neuroimaging-integrated framework can better capture this complexity and guide more-personalized, mechanism-based psychedelic therapies.

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DO - 10.1038/s44220-025-00551-y

M3 - Comments/Debates

AN - SCOPUS:105023681748

SN - 2731-6076

VL - 3

SP - 1465

EP - 1467

JO - Nature Mental Health

JF - Nature Mental Health

IS - 12

ER -

Not all psychedelics are created equal

Abstract

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