No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

Anders M. Fjell; Øystein Sørensen; Yunpeng Wang; Inge K. Amlien; William F.C. Baaré; David Bartrés-Faz; Lars Bertram; Carl Johan Boraxbekk; Andreas M. Brandmaier; Ilja Demuth; Christian A. Drevon; Klaus P. Ebmeier; Paolo Ghisletta; Rogier Kievit; Simone Kühn; Kathrine Skak Madsen; Athanasia M. Mowinckel; Lars Nyberg; Claire E. Sexton; Cristina Solé-Padullés; Didac Vidal-Piñeiro; Gerd Wagner; Leiv Otto Watne; Kristine B. Walhovd

doi:10.1038/s41562-023-01707-5

No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

Anders M. Fjell^*, Øystein Sørensen, Yunpeng Wang, Inge K. Amlien, William F.C. Baaré, David Bartrés-Faz, Lars Bertram, Carl Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kühn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Solé-PadullésDidac Vidal-Piñeiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd

^*Korrespondierende/r Autor/-in für diese Arbeit

22 Zitate (Scopus)

Abstract

Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration—which is shorter than current recommendations.

Originalsprache	Englisch
Zeitschrift	Nature Human Behaviour
Jahrgang	7
Ausgabenummer	11
Seiten (von - bis)	2008-2022
Seitenumfang	15
DOIs	https://doi.org/10.1038/s41562-023-01707-5
Publikationsstatus	Veröffentlicht - 11.2023

Fördermittel

The Lifebrain consortium is funded by the EU Horizon 2020 grant agreement no. 732592 (Lifebrain). The different sub-studies are supported by different sources. LCBC is supported by the European Research Council under grant agreements no. 283634 and no. 725025 (to A.M.F.) and no. 313440 (to K.B.W.), as well as the Norwegian Research Council (to A.M.F. and K.B.W.) and the National Association for Public Health’s dementia research programme, Norway (to A.M.F.). Betula is supported by a scholar grant from the Knut and Alice Wallenberg foundation to L.N. Barcelona is partially supported by a Spanish Ministry of Economy and Competitiveness grant to D.B.-F. (grant no. PSI2015-64227-R (AEI/FEDER, UE)); by the Walnuts and Healthy Aging study ( http://www.clinicaltrials.gov ; grant no. NCT01634841) funded by the California Walnut Commission, Sacramento, California; and by an ICREA Academia 2019 award. BASE-II has been supported by the German Federal Ministry of Education and Research under grant nos 16SV5537, 16SV5837, 16SV5538, 16SV5536K, 01UW0808, 01UW0706, 01GL1716A and 01GL1716B and by the European Research Council under grant agreement no. 677804 (to S.K.). Work on the Whitehall II Imaging Substudy was mainly funded by Lifelong Health and Well-being Programme grant no. G1001354 from the UK Medical Research Council (‘Predicting MRI Abnormalities with Longitudinal Data of the Whitehall II Substudy’) to K.P.E. The Wellcome Centre for Integrative Neuroimaging is supported by core funding from award no. 203139/Z/16/Z from the Wellcome Trust. The data were provided (in part) by the Human Connectome Project, WU-Minn Consortium (principal investigators: D. Van Essen and K. Ugurbil; 1U54MH091657), funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. Part of the research was conducted using the UKB resource under application no. 32048. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Träger	Trägernummer
California Walnut Commission
Knut och Alice Wallenbergs Stiftelse
Norges Idrettshøgskole
National Association for Public Health
Norges Forskningsråd
Agencia Estatal de Investigación
Horizon 2020
WU-Minn Consortium	1U54MH091657
Bundesministerium für Bildung und Forschung	677804, 16SV5536K, 01GL1716B, 01GL1716A, 01UW0808, 01UW0706, 16SV5538, 16SV5537, 16SV5837
Horizon 2020 Framework Programme	732592
McDonnell Center for Systems Neuroscience	32048
European Regional Development Fund	NCT01634841
Wellcome Trust	203139
Ministerio de Economía y Competitividad	PSI2015-64227-R
European Research Council	283634, 725025, 313440
Lifelong Health and Well-being Programme	G1001354
Medical Research Council	203139/Z/16/Z

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
Querschnittsbereich: Medizinische Genetik

DFG-Fachsystematik

2.23-06 Molekulare und zelluläre Neurologie und Neuropathologie

KDSF-Klassifikation für Forschungsfelder

231 - Zellen und Gene

Dokumente

10.1038/s41562-023-01707-5

Weitere Links

Link to publication in Scopus

Entwicklung und Validierung von DNA-Methylation-Clocks unter Nutzung von Verlaufsdaten der Berliner Altersstudie II (BASE-II)
Bertram, L. (Projektleiter*in (PI)) & Demuth, I. (Projektleiter*in (PI))
01.01.21 → 31.12.25
Projekt: DFG Einzelprojekte › DFG Einzelförderungen (Sachbeihilfen)

Zitieren

Fjell, A. M., Sørensen, Ø., Wang, Y., Amlien, I. K., Baaré, W. F. C., Bartrés-Faz, D., Bertram, L., Boraxbekk, C. J., Brandmaier, A. M., Demuth, I., Drevon, C. A., Ebmeier, K. P., Ghisletta, P., Kievit, R., Kühn, S., Madsen, K. S., Mowinckel, A. M., Nyberg, L., Sexton, C. E., ... Walhovd, K. B. (2023). No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. Nature Human Behaviour, 7(11), 2008-2022. https://doi.org/10.1038/s41562-023-01707-5

@article{c43658bb64ce426da78c91fc1c973b3f,

title = "No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy",

abstract = "Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95\% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration—which is shorter than current recommendations.",

author = "Fjell, \{Anders M.\} and {\O}ystein S{\o}rensen and Yunpeng Wang and Amlien, \{Inge K.\} and Baar{\'e}, \{William F.C.\} and David Bartr{\'e}s-Faz and Lars Bertram and Boraxbekk, \{Carl Johan\} and Brandmaier, \{Andreas M.\} and Ilja Demuth and Drevon, \{Christian A.\} and Ebmeier, \{Klaus P.\} and Paolo Ghisletta and Rogier Kievit and Simone K{\"u}hn and Madsen, \{Kathrine Skak\} and Mowinckel, \{Athanasia M.\} and Lars Nyberg and Sexton, \{Claire E.\} and Cristina Sol{\'e}-Padull{\'e}s and Didac Vidal-Pi{\~n}eiro and Gerd Wagner and Watne, \{Leiv Otto\} and Walhovd, \{Kristine B.\}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = nov,

doi = "10.1038/s41562-023-01707-5",

language = "English",

volume = "7",

pages = "2008--2022",

journal = "Nature Human Behaviour",

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Fjell, AM, Sørensen, Ø, Wang, Y, Amlien, IK, Baaré, WFC, Bartrés-Faz, D, Bertram, L, Boraxbekk, CJ, Brandmaier, AM, Demuth, I, Drevon, CA, Ebmeier, KP, Ghisletta, P, Kievit, R, Kühn, S, Madsen, KS, Mowinckel, AM, Nyberg, L, Sexton, CE, Solé-Padullés, C, Vidal-Piñeiro, D, Wagner, G, Watne, LO & Walhovd, KB 2023, 'No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy', Nature Human Behaviour, Jg. 7, Nr. 11, S. 2008-2022. https://doi.org/10.1038/s41562-023-01707-5

TY - JOUR

T1 - No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

AU - Fjell, Anders M.

AU - Sørensen, Øystein

AU - Wang, Yunpeng

AU - Amlien, Inge K.

AU - Baaré, William F.C.

AU - Bartrés-Faz, David

AU - Bertram, Lars

AU - Boraxbekk, Carl Johan

AU - Brandmaier, Andreas M.

AU - Demuth, Ilja

AU - Drevon, Christian A.

AU - Ebmeier, Klaus P.

AU - Ghisletta, Paolo

AU - Kievit, Rogier

AU - Kühn, Simone

AU - Madsen, Kathrine Skak

AU - Mowinckel, Athanasia M.

AU - Nyberg, Lars

AU - Sexton, Claire E.

AU - Solé-Padullés, Cristina

AU - Vidal-Piñeiro, Didac

AU - Wagner, Gerd

AU - Watne, Leiv Otto

AU - Walhovd, Kristine B.

PY - 2023/11

Y1 - 2023/11

N2 - Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration—which is shorter than current recommendations.

AB - Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration—which is shorter than current recommendations.

UR - https://www.scopus.com/pages/publications/85166337428

U2 - 10.1038/s41562-023-01707-5

DO - 10.1038/s41562-023-01707-5

M3 - Journal articles

C2 - 37798367

AN - SCOPUS:85166337428

SN - 2397-3374

VL - 7

SP - 2008

EP - 2022

JO - Nature Human Behaviour

JF - Nature Human Behaviour

IS - 11

ER -

No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

KDSF-Klassifikation für Forschungsfelder

Dokumente

Weitere Links

Fingerprint

Projekte

Entwicklung und Validierung von DNA-Methylation-Clocks unter Nutzung von Verlaufsdaten der Berliner Altersstudie II (BASE-II)

Zitieren