Abstract
The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter transgene, nuclear translocation of NF-κB in neurons and enhanced DNA binding of NF-κB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death- promoting role of NF-κB in focal ischemia. NF-κB may provide a new pharmacological target in neurologic disease.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Nature Medicine |
| Jahrgang | 5 |
| Ausgabenummer | 5 |
| Seiten (von - bis) | 554-559 |
| Seitenumfang | 6 |
| ISSN | 1078-8956 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 01.05.1999 |
Fördermittel
Acknowledgment We thank P. Chan for help with establishing the filament model in mice; and S. Prinz, N. Attigah, and Y. Xu for their help at various stages of the project. This work was supported by a grant of the DFG to M.S.
UN SDGs
Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung
-
SDG 3 – Gesundheit und Wohlergehen
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
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