TY - JOUR
T1 - New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases
AU - Boltze, Johannes
AU - Aronowski, Jaroslaw A.
AU - Badaut, Jerome
AU - Buckwalter, Marion S.
AU - Caleo, Mateo
AU - Chopp, Michael
AU - Dave, Kunjan R.
AU - Didwischus, Nadine
AU - Dijkhuizen, Rick M.
AU - Doeppner, Thorsten R.
AU - Dreier, Jens P.
AU - Fouad, Karim
AU - Gelderblom, Mathias
AU - Gertz, Karen
AU - Golubczyk, Dominika
AU - Gregson, Barbara A.
AU - Hamel, Edith
AU - Hanley, Daniel F.
AU - Härtig, Wolfgang
AU - Hummel, Friedhelm C.
AU - Ikhsan, Maulana
AU - Janowski, Miroslaw
AU - Jolkkonen, Jukka
AU - Karuppagounder, Saravanan S.
AU - Keep, Richard F.
AU - Koerte, Inga K.
AU - Kokaia, Zaal
AU - Li, Peiying
AU - Liu, Fudong
AU - Lizasoain, Ignacio
AU - Ludewig, Peter
AU - Metz, Gerlinde A.S.
AU - Montagne, Axel
AU - Obenaus, Andre
AU - Palumbo, Alex
AU - Pearl, Monica
AU - Perez-Pinzon, Miguel
AU - Planas, Anna M.
AU - Plesnila, Nikolaus
AU - Raval, Ami P.
AU - Rueger, Maria A.
AU - Sansing, Lauren H.
AU - Sohrabji, Farida
AU - Stagg, Charlotte J.
AU - Stetler, R. Anne
AU - Stowe, Ann M.
AU - Sun, Dandan
AU - Taguchi, Akihiko
AU - Tanter, Mickael
AU - Vay, Sabine U.
AU - Vemuganti, Raghu
AU - Vivien, Denis
AU - Walczak, Piotr
AU - Wang, Jian
AU - Xiong, Ye
AU - Zille, Marietta
N1 - Publisher Copyright:
© Copyright © 2021 Boltze, Aronowski, Badaut, Buckwalter, Caleo, Chopp, Dave, Didwischus, Dijkhuizen, Doeppner, Dreier, Fouad, Gelderblom, Gertz, Golubczyk, Gregson, Hamel, Hanley, Härtig, Hummel, Ikhsan, Janowski, Jolkkonen, Karuppagounder, Keep, Koerte, Kokaia, Li, Liu, Lizasoain, Ludewig, Metz, Montagne, Obenaus, Palumbo, Pearl, Perez-Pinzon, Planas, Plesnila, Raval, Rueger, Sansing, Sohrabji, Stagg, Stetler, Stowe, Sun, Taguchi, Tanter, Vay, Vemuganti, Vivien, Walczak, Wang, Xiong and Zille.
PY - 2021/1/28
Y1 - 2021/1/28
N2 - The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.
AB - The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.
UR - http://www.scopus.com/inward/record.url?scp=85101013209&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2021.623751
DO - 10.3389/fnagi.2021.623751
M3 - Journal articles
C2 - 33584250
AN - SCOPUS:85101013209
SN - 1663-4365
VL - 13
SP - 623751
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 623751
ER -