Abstract
Human polymorphonuclear neutrophils (PMN) are regulated by soluble factors such as chemotactic peptides and cytokines. PMN themselves are capable of synthesizing and releasing various cytokines, thereby taking part in the afferent or inductive limb of the immune response. We report for the first time that TGFβ2 can be synthesized and released by PMN obtained from peripheral blood. Reverse transcriptase polymerase chain reaction (RT-PCR) showed that preparations of PMN express mRNA for transforming growth factor (TGF)β1 and TGFβ2 but not for TGFβ3. Only translation of TGFβ2 into protein was observed applying different assays. Interestingly, TGFβ2 in supernatants from stimulated PMN could be detected in the bioactive form. (C) 2000 Academic Press.
| Originalsprache | Englisch |
|---|---|
| Zeitschrift | Cytokine |
| Jahrgang | 12 |
| Ausgabenummer | 4 |
| Seiten (von - bis) | 397-400 |
| Seitenumfang | 4 |
| ISSN | 1043-4666 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 04.2000 |
Fördermittel
The author would like to thank I. Mons and K. Bartels for excellent technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft (SFB 387), Bonn, Germany.
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)
UN SDGs
Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung
