Neutrophils in aging and aging-related pathologies

Kristof Van Avondt; Jan Kolja Strecker; Claudia Tulotta; Jens Minnerup; Christian Schulz; Oliver Soehnlein

doi:10.1111/imr.13153

Neutrophils in aging and aging-related pathologies

Kristof Van Avondt^*, Jan Kolja Strecker, Claudia Tulotta, Jens Minnerup, Christian Schulz, Oliver Soehnlein^*

^*Korrespondierende/r Autor/-in für diese Arbeit

123 Zitate (Scopus)

Abstract

Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

Originalsprache	Englisch
Zeitschrift	Immunological Reviews
Jahrgang	314
Ausgabenummer	1
Seiten (von - bis)	357-375
Seitenumfang	19
ISSN	0105-2896
DOIs	https://doi.org/10.1111/imr.13153
Publikationsstatus	Veröffentlicht - 03.2023

Fördermittel

K.V.A. receives funding from the IMF at the Münster Medical Faculty; C.T. is supported by the Humboldt Foundation and the Marie Curie actions; J.M. is supported by the Interdisciplinary Center for Clinical Research (IZKF) Münster and by the Deutsche Forschungsgemeinschaft (MI 1547/3‐1, MI 1547/4–1, FOR 2879/1, CRC TRR332 TP B2); C.S. receives support from German Center for Cardiovascular Research (DZHK) and the BMBF (project 81Z060020) and the Deutsche Forschungsgemeinschaft (CRC914 TP A10, CRC1123 TP A7, CRC TRR332 TP A6, SCHU 2297/1‐1); O.S. receives funding from the Deutsche Forschungsgemeinschaft (CRC TRR332 TP A2 & Z1, CRC914 TP B8, CRC1009 TP A13, CRC1123 TP A6, OR465/1‐1), the Else Kröner Fresenius Stiftung, the IZKF at the Münster Medical Faculty, Novo Nordisk, and the Leducq Foundation. The authors would like to thank Nina Knubel for generating the display items. Open Access funding enabled and organized by Projekt DEAL.

Träger	Trägernummer
International Myeloma Foundation
Alexander von Humboldt Stiftung
Deutsches Zentrum für Herz-Kreislaufforschung
Deutsche Forschungsgemeinschaft	CRC TRR332 TP B2, MI 1547/4–1, MI 1547/3‐1, FOR 2879/1
Fondation Leducq
Bundesministerium für Bildung und Forschung	CRC914 TP B8, CRC TRR332 TP A2 & Z1, CRC1123 TP A6, CRC1123 TP A7, CRC914 TP A10, SCHU 2297/1‐1, CRC1009 TP A13, CRC TRR332 TP A6, OR465/1‐1, 81Z060020
Else Kröner-Fresenius-Stiftung
Novo Nordisk Foundation
Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 6 – Sauberes Wasser und sanitäre Einrichtungen
SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

DFG-Fachsystematik

2.21-03 Medizinische Mikrobiologie und Mykologie, Hygiene, Molekulare Infektionsbiologie
2.23-07 Klinische Neurologie, Neurochirurgie und Neuroradiologie
2.21-05 Immunologie

Dokumente

10.1111/imr.13153

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title = "Neutrophils in aging and aging-related pathologies",

abstract = "Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.",

author = "\{Van Avondt\}, Kristof and Strecker, \{Jan Kolja\} and Claudia Tulotta and Jens Minnerup and Christian Schulz and Oliver Soehnlein",

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year = "2023",

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doi = "10.1111/imr.13153",

language = "English",

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AU - Van Avondt, Kristof

AU - Strecker, Jan Kolja

AU - Tulotta, Claudia

AU - Minnerup, Jens

AU - Schulz, Christian

AU - Soehnlein, Oliver

PY - 2023/3

Y1 - 2023/3

N2 - Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

AB - Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

UR - https://www.scopus.com/pages/publications/85141374900

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DO - 10.1111/imr.13153

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SP - 357

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ER -

Neutrophils in aging and aging-related pathologies

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

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