Neuronal electrical high frequency stimulation enhances GABA outflow from human neocortical slices

M. Mantovani, V. Van Velthoven, H. Fuellgraf, T. J. Feuerstein, A. Moser*

*Korrespondierende/r Autor/-in für diese Arbeit
23 Zitate (Scopus)

Abstract

Electrical high frequency stimulation of the globus pallidus internus or the subthalamic nucleus has beneficial motor effects in advanced Parkinson's disease. The mechanisms underlying these clinical results remain, however, unclear. From previous studies it is proposed that the γ-aminobutyric acid (GABA) system is involved in the effectiveness of electrical high frequency stimulation. In these experiments, human neocortical slices were stimulated electrically (130 Hz) in vitro, and GABA outflow was measured after o-phthaldialdehyde sulphite derivatization using HPLC with electrochemical detection. Our results could demonstrate that high frequency stimulation (HFS) significantly increased basal GABA outflow in the presence of submaximal concentrations of the voltage-gated sodium channel opener veratridine. This effect could be abolished by the GABA antagonists bicuculline or picrotoxin. These results suggest that HFS has an activating effect on GABAergic neuronal terminals in human neocortical slices, depending on sodium and chloride influx. Since GABA plays a role in CNS disorders of basal ganglia, anxiety and epilepsy, its neocortical modulation by HFS may be (patho)physiologically relevant.

OriginalspracheEnglisch
ZeitschriftNeurochemistry International
Jahrgang49
Ausgabenummer4
Seiten (von - bis)347-350
Seitenumfang4
ISSN0197-0186
DOIs
PublikationsstatusVeröffentlicht - 01.09.2006

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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