Neuroendocrine Neoplasms of the Digestive System

Irene Esposito, Günter Klöppel, Irene Esposito, Atsuko Kasajima, Stefano La Rosa, Levent Dizdar, Wolfram Trudo Knoefel, Matthias Schott, Clarisse Dromain, Nicolas Villard, Lena Häberle, Björn Konukiewitz, Aurel Perren, Ilaria Marinoni, Bence Sipos, Inga Boeck, Martin Anlauf, Moritz Jesinghaus, Silvia Uccella, Christoph RoderburgHenning Jann, Emil Novruzov, Katalin Mattes-György, Frederik L. Giesel, Pietro Antonini, Antonio Pea, Alessandra Pulvirenti, Claudio Luchini

Abstract

The digestive system represents the most common localization for neuroendocrine neoplasms (NEN) in the human body. Despite a common classification and some unifying characteristics, for example the tissue and serum markers used for their identification and characterization and their features at imaging, NEN of the digestive system display a high level of morphological, molecular, clinical, and biological heterogeneity. This is partially related to distinct causative factors and pathogenetic mechanisms, which are peculiar to the specific localizations in the digestive system. This chapter presents a comprehensive overview of NEN of the digestive system with focus on their epidemiology, histopathology, molecular biology, imaging characteristics, and therapeutic options. Subchapters deal with the problematic of differential diagnosis and treatment of hepatic metastases of NEN, which frequently represent a clinical challenge, and with NEN occurring in the context of genetic syndromes.[Aspects of disease that affect the small bowel are also covered in Chapter Unavailable ].

OriginalspracheEnglisch
TitelGastrointestinal Oncology: A Critical Multidisciplinary Team Approach : A Critical Multidisciplinary Team Approach
Seitenumfang1
Herausgeber (Verlag)Wiley
Erscheinungsdatum01.01.2024
Seiten470-470
ISBN (Print)9781119756392
ISBN (elektronisch)9781119756422
DOIs
PublikationsstatusVeröffentlicht - 01.01.2024

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

  • 2.22-17 Endokrinologie, Diabetologie, Metabolismus
  • 2.23-06 Molekulare und zelluläre Neurologie und Neuropathologie

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