Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt; Paul Allen; Sagnik Bhattacharyya; Paolo Fusar-Poli; Jose A. Crippa; Marc L. Seal; Valter Fraccaro; Zerrin Atakan; Rocio Martin-Santos; Colin O'Carroll; Katya Rubia; Philip K. McGuire

doi:10.1016/j.biopsych.2008.05.011

Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt^*, Paul Allen, Sagnik Bhattacharyya, Paolo Fusar-Poli, Jose A. Crippa, Marc L. Seal, Valter Fraccaro, Zerrin Atakan, Rocio Martin-Santos, Colin O'Carroll, Katya Rubia, Philip K. McGuire

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Psychiatrie und Psychotherapie

174 Zitate (Scopus)

Abstract

Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

Originalsprache	Englisch
Zeitschrift	Biological Psychiatry
Jahrgang	64
Ausgabenummer	11
Seiten (von - bis)	966-973
Seitenumfang	8
ISSN	0006-3223
DOIs	https://doi.org/10.1016/j.biopsych.2008.05.011
Publikationsstatus	Veröffentlicht - 01.12.2008

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This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's & St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content.

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10.1016/j.biopsych.2008.05.011

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title = "Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition",

abstract = "Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.",

author = "Borgwardt, \{Stefan J.\} and Paul Allen and Sagnik Bhattacharyya and Paolo Fusar-Poli and Crippa, \{Jose A.\} and Seal, \{Marc L.\} and Valter Fraccaro and Zerrin Atakan and Rocio Martin-Santos and Colin O'Carroll and Katya Rubia and McGuire, \{Philip K.\}",

note = "Funding Information: This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's \& St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content. ",

year = "2008",

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doi = "10.1016/j.biopsych.2008.05.011",

language = "English",

volume = "64",

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TY - JOUR

T1 - Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol

T2 - Effects During Response Inhibition

AU - Borgwardt, Stefan J.

AU - Allen, Paul

AU - Bhattacharyya, Sagnik

AU - Fusar-Poli, Paolo

AU - Crippa, Jose A.

AU - Seal, Marc L.

AU - Fraccaro, Valter

AU - Atakan, Zerrin

AU - Martin-Santos, Rocio

AU - O'Carroll, Colin

AU - Rubia, Katya

AU - McGuire, Philip K.

N1 - Funding Information: This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's & St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

AB - Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

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U2 - 10.1016/j.biopsych.2008.05.011

DO - 10.1016/j.biopsych.2008.05.011

M3 - Journal articles

C2 - 18589404

AN - SCOPUS:55349114694

SN - 0006-3223

VL - 64

SP - 966

EP - 973

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 11

ER -

Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Abstract

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