Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Anna C. Bakenecker; Anselm von Gladiss; Hannes Schwenke; André Behrends; Thomas Friedrich; Kerstin Lüdtke-Buzug; Alexander Neumann; Joerg Barkhausen; Franz Wegner; Thorsten M. Buzug

doi:10.1038/s41598-021-93323-4

Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Anna C. Bakenecker^*, Anselm von Gladiss, Hannes Schwenke, André Behrends, Thomas Friedrich, Kerstin Lüdtke-Buzug, Alexander Neumann, Joerg Barkhausen, Franz Wegner, Thorsten M. Buzug

^*Korrespondierende/r Autor/-in für diese Arbeit

70 Zitate (Scopus)

Abstract

Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

Originalsprache	Englisch
Aufsatznummer	14082
Zeitschrift	Scientific Reports
Jahrgang	11
Ausgabenummer	1
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-021-93323-4
Publikationsstatus	Veröffentlicht - 12.2021

Fördermittel

Open Access funding enabled and organized by Projekt DEAL. The authors gratefully acknowledge the Federal Ministry of Education and Research, Germany (BMBF) for funding this project under Grant Numbers 13GW0230B (FMT), 13GW0069A (SAMBA PATI), 01DL17010A (IMAGINE) and 13GW0071D (SKAMPI).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 9 – Industrie, Innovation und Infrastruktur

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Biomedizintechnik

DFG-Fachsystematik

2.22-32 Medizinische Physik, Biomedizinische Technik
2.22-30 Radiologie

Dokumente

10.1038/s41598-021-93323-4

Weitere Links

Link to publication in Scopus

Zitieren

@article{8d57cf6a28594059b099701aad0067cd,

title = "Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging",

abstract = "Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.",

author = "Bakenecker, \{Anna C.\} and \{von Gladiss\}, Anselm and Hannes Schwenke and Andr{\'e} Behrends and Thomas Friedrich and Kerstin L{\"u}dtke-Buzug and Alexander Neumann and Joerg Barkhausen and Franz Wegner and Buzug, \{Thorsten M.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41598-021-93323-4",

language = "English",

volume = "11",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Springer Science and Business Media, LLC",

number = "1",

}

TY - JOUR

T1 - Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

AU - Bakenecker, Anna C.

AU - von Gladiss, Anselm

AU - Schwenke, Hannes

AU - Behrends, André

AU - Friedrich, Thomas

AU - Lüdtke-Buzug, Kerstin

AU - Neumann, Alexander

AU - Barkhausen, Joerg

AU - Wegner, Franz

AU - Buzug, Thorsten M.

PY - 2021/12

Y1 - 2021/12

N2 - Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

AB - Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

UR - https://www.scopus.com/pages/publications/85109358675

U2 - 10.1038/s41598-021-93323-4

DO - 10.1038/s41598-021-93323-4

M3 - Journal articles

C2 - 34234207

AN - SCOPUS:85109358675

SN - 2045-2322

VL - 11

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 14082

ER -

Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

Weitere Links

Fingerprint

Zitieren