Mutual influence of sleep and circadian clocks on physiology and cognition

Isabel Heyde; Jana Thabea Kiehn; Henrik Oster

doi:10.1016/j.freeradbiomed.2017.11.003

Mutual influence of sleep and circadian clocks on physiology and cognition

Isabel Heyde, Jana Thabea Kiehn, Henrik Oster^*

^*Korrespondierende/r Autor/-in für diese Arbeit

27 Zitate (Scopus)

Abstract

The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.

Originalsprache	Englisch
Zeitschrift	Free Radical Biology and Medicine
Jahrgang	119
Seiten (von - bis)	8-16
Seitenumfang	9
ISSN	0891-5849
DOIs	https://doi.org/10.1016/j.freeradbiomed.2017.11.003
Publikationsstatus	Veröffentlicht - 01.05.2018

Fördermittel

This work was funded by the Deutsche Forschungsgemeinschaft (GRK-1957 and TR-SFB-134) and the Volkswagen Foundation (Lichtenberg Program).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 8 – Angemessene Arbeitsbedingungen und wirtschaftliches Wachstum
SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.1016/j.freeradbiomed.2017.11.003

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title = "Mutual influence of sleep and circadian clocks on physiology and cognition",

abstract = "The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.",

author = "Isabel Heyde and Kiehn, \{Jana Thabea\} and Henrik Oster",

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AU - Heyde, Isabel

AU - Kiehn, Jana Thabea

AU - Oster, Henrik

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Y1 - 2018/5/1

N2 - The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.

AB - The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.

UR - https://www.scopus.com/pages/publications/85034433532

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DO - 10.1016/j.freeradbiomed.2017.11.003

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SN - 0891-5849

VL - 119

SP - 8

EP - 16

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Mutual influence of sleep and circadian clocks on physiology and cognition

Abstract

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UN SDGs

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