Multi-MHz retinal OCT

Thomas Klein, Wolfgang Wieser, Lukas Reznicek, Aljoscha Neubauer, Anselm Kampik, Robert Huber

108 Zitate (Scopus)


We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging of the human retina at A-scan rates in excess of 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line rates are investigated, and a simple multi-volume data processing approach is presented. In-vivo OCT of the human ocular fundus is performed at different axial scan rates of up to 6.7 MHz. High quality non-mydriatic retinal imaging over an ultra-wide field is achieved by a combination of several key improvements compared to previous setups. For the FDML laser, long coherence lengths and 72 nm wavelength tuning range are achieved using a chirped fiber Bragg grating in a laser cavity at 419.1 kHz fundamental tuning rate. Very large data sets can be acquired with sustained data transfer from the data acquisition card to host computer memory, enabling high-quality averaging of many frames and of multiple aligned data sets. Three imaging modes are investigated: Alignment and averaging of 24 data sets at 1.68 MHz axial line rate, ultra-dense transverse sampling at 3.35 MHz line rate, and dual-beam imaging with two laser spots on the retina at an effective line rate of 6.7 MHz.

ZeitschriftBiomedical Optics Express
Seiten (von - bis)1890-1908
PublikationsstatusVeröffentlicht - 01.01.2013


Untersuchen Sie die Forschungsthemen von „Multi-MHz retinal OCT“. Zusammen bilden sie einen einzigartigen Fingerprint.