Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors

Ulrich Schäfer; Christof Burgdorf; Astrid Engelhardt; Walter Raasch; Thomas Kurz; Gert Richardt

doi:10.1196/annals.1304.033

Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors

Ulrich Schäfer, Christof Burgdorf, Astrid Engelhardt, Walter Raasch, Thomas Kurz, Gert Richardt

Abstract

The function of presynaptic imidazoline-1 receptors (I1-R) in the heart remains unclear. In rat hearts, UK14.304 and moxonidine reduced norepinephrine (NE) release. AGN192403 had no influence on NE, whereas rilmenidine, agmatine, rauwolscine, and efaroxan increased NE. These effects of moxonidine and rilmenidine were not affected by AGN192403 adminstration. Conversely, after pretreatment with UK14.304, only moxonidine displayed a pronounced inhibitory action on NE release (sensitive to AGN192403), indicating a synergistic inhibitory action at I1-R under conditions of a stimulated alpha2-adrenergic autoinhibition.

Originalsprache	Englisch
Zeitschrift	Annals of the New York Academy of Sciences
Jahrgang	1009
Seiten (von - bis)	265-9
Seitenumfang	5
ISSN	0077-8923
DOIs	https://doi.org/10.1196/annals.1304.033
Publikationsstatus	Veröffentlicht - 2003

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@article{a997a4aff33e4c11b92b305abfbe2eb8,

title = "Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors",

abstract = "The function of presynaptic imidazoline-1 receptors (I1-R) in the heart remains unclear. In rat hearts, UK14.304 and moxonidine reduced norepinephrine (NE) release. AGN192403 had no influence on NE, whereas rilmenidine, agmatine, rauwolscine, and efaroxan increased NE. These effects of moxonidine and rilmenidine were not affected by AGN192403 adminstration. Conversely, after pretreatment with UK14.304, only moxonidine displayed a pronounced inhibitory action on NE release (sensitive to AGN192403), indicating a synergistic inhibitory action at I1-R under conditions of a stimulated alpha2-adrenergic autoinhibition.",

author = "Ulrich Sch{\"a}fer and Christof Burgdorf and Astrid Engelhardt and Walter Raasch and Thomas Kurz and Gert Richardt",

year = "2003",

doi = "10.1196/annals.1304.033",

language = "English",

volume = "1009",

pages = "265--9",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc",

}

Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors. / Schäfer, Ulrich; Burgdorf, Christof; Engelhardt, Astrid et al.
in: Annals of the New York Academy of Sciences, Jahrgang 1009, 2003, S. 265-9.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors

AU - Schäfer, Ulrich

AU - Burgdorf, Christof

AU - Engelhardt, Astrid

AU - Raasch, Walter

AU - Kurz, Thomas

AU - Richardt, Gert

PY - 2003

Y1 - 2003

N2 - The function of presynaptic imidazoline-1 receptors (I1-R) in the heart remains unclear. In rat hearts, UK14.304 and moxonidine reduced norepinephrine (NE) release. AGN192403 had no influence on NE, whereas rilmenidine, agmatine, rauwolscine, and efaroxan increased NE. These effects of moxonidine and rilmenidine were not affected by AGN192403 adminstration. Conversely, after pretreatment with UK14.304, only moxonidine displayed a pronounced inhibitory action on NE release (sensitive to AGN192403), indicating a synergistic inhibitory action at I1-R under conditions of a stimulated alpha2-adrenergic autoinhibition.

AB - The function of presynaptic imidazoline-1 receptors (I1-R) in the heart remains unclear. In rat hearts, UK14.304 and moxonidine reduced norepinephrine (NE) release. AGN192403 had no influence on NE, whereas rilmenidine, agmatine, rauwolscine, and efaroxan increased NE. These effects of moxonidine and rilmenidine were not affected by AGN192403 adminstration. Conversely, after pretreatment with UK14.304, only moxonidine displayed a pronounced inhibitory action on NE release (sensitive to AGN192403), indicating a synergistic inhibitory action at I1-R under conditions of a stimulated alpha2-adrenergic autoinhibition.

U2 - 10.1196/annals.1304.033

DO - 10.1196/annals.1304.033

M3 - Journal articles

C2 - 15028597

SN - 0077-8923

VL - 1009

SP - 265

EP - 269

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors

Abstract

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