'Moving genes': how dystonia genes functionally converge on the transcriptome

Despite sharing the consensus clinical definition of a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements and/or postures, the dystonias are a clinically and aetiologically heterogeneous group. They vary greatly in terms of age and site of onset, body distribution, genetic contribution, presence or absence of neurodegeneration, and response to treatment, to name only the most important characteristics of dystonia (Albanese et al., 2013). Even the inherited dystonias—the total number of...