Molecular Recognition of UDP-Gal by β-1,4-Galactosyltransferase T1

Thorsten Biet; Thomas Peters

doi:10.1002/1521-3773(20011119)40:22<4189::AID-ANIE4189>3.0.CO;2-A

Molecular Recognition of UDP-Gal by β-1,4-Galactosyltransferase T1

Thorsten Biet, Thomas Peters^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Chemie und Metabolomics

32 Zitate (Scopus)

Abstract

Saturation transfer difference (STD) NMR experiments reveal the binding epitopes of UDP-Gal and UDP-Glc bound to the glycosyltransferase β4Gal-T1 (see picture). Whereas the enzyme recognizes the galactose residue in UDP-Gal, it does not make any close contacts with the glucose residue in UDP-Glc. This observation explains why β4Gal-T1 binds to UDP-Glc but is unable to transfer glucose to an acceptor substrate.

Originalsprache	Englisch
Zeitschrift	Angewandte Chemie - International Edition
Jahrgang	40
Ausgabenummer	22
Seiten (von - bis)	4189-4192
Seitenumfang	4
ISSN	1433-7851
DOIs	https://doi.org/10.1002/1521-3773(20011119)40:22<4189::AID-ANIE4189>3.0.CO;2-A
Publikationsstatus	Veröffentlicht - 19.11.2001

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Molecular Recognition of UDP-Gal by β-1,4-Galactosyltransferase T1

Abstract

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