Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy

Brigitte Fiege; Christoph Rademacher; Jonathan Cartmell; Pavel I. Kitov; Francisco Parra; Thomas Peters

doi:10.1002/anie.201105719

Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy

Brigitte Fiege^*, Christoph Rademacher, Jonathan Cartmell, Pavel I. Kitov, Francisco Parra, Thomas Peters

^*Korrespondierende/r Autor/-in für diese Arbeit

64 Zitate (Scopus)

Abstract

Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.

Originalsprache	Englisch
Zeitschrift	Angewandte Chemie - International Edition
Jahrgang	51
Ausgabenummer	4
Seiten (von - bis)	928-932
Seitenumfang	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201105719
Publikationsstatus	Veröffentlicht - 23.01.2012

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SDG 3 – Gesundheit und Wohlergehen

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1002/anie.201105719

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title = "Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy",

abstract = "Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.",

author = "Brigitte Fiege and Christoph Rademacher and Jonathan Cartmell and Kitov, \{Pavel I.\} and Francisco Parra and Thomas Peters",

year = "2012",

month = jan,

day = "23",

doi = "10.1002/anie.201105719",

language = "English",

volume = "51",

pages = "928--932",

journal = "Angewandte Chemie - International Edition",

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Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy. / Fiege, Brigitte; Rademacher, Christoph; Cartmell, Jonathan et al.
in: Angewandte Chemie - International Edition, Jahrgang 51, Nr. 4, 23.01.2012, S. 928-932.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy

AU - Fiege, Brigitte

AU - Rademacher, Christoph

AU - Cartmell, Jonathan

AU - Kitov, Pavel I.

AU - Parra, Francisco

AU - Peters, Thomas

PY - 2012/1/23

Y1 - 2012/1/23

N2 - Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.

AB - Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.

UR - https://www.scopus.com/pages/publications/84856006189

U2 - 10.1002/anie.201105719

DO - 10.1002/anie.201105719

M3 - Journal articles

C2 - 22170811

AN - SCOPUS:84856006189

SN - 1433-7851

VL - 51

SP - 928

EP - 932

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 4

ER -

Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy

Abstract

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