Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis

Johannes Textor; Jürgen Westermann

doi:10.1007/978-3-540-73922-7_20

Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis

^*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

The migration of lymphocytes through secondary lymphoid organs was believed to be mainly controlled by chemokine gradients. This theory has recently been called into question since naive lymphocytes observed in vivo by two-photon microscopy show no evidence of directed migration. We have constructed a simple mathematical model of naive T cell migration in lymph nodes that is solely based on local mechanisms. The model was validated against findings from histological analysis and experimentally determined lymphocyte recirculation kinetics. Our results suggest that T cell compartmentalization in lymph nodes can be explained without long-range chemokine gradients. However, the T cell residence time predicted by our model is significantly lower than observed in vivo, indicating the existence of a mechanism which alters the T cell random walk over time.

Originalsprache	Englisch
Titel	ICARIS 2007: Artificial Immune Systems
Redakteure/-innen	Leandro Nunes de Castro, Fernando José Von Zuben, Helder Knidel
Seitenumfang	12
Band	4628 LNCS
Herausgeber (Verlag)	Springer-Verlag Berlin Heidelberg
Erscheinungsdatum	2007
Seiten	228-239
ISBN (Print)	978-3-540-73921-0
ISBN (elektronisch)	978-3-540-73922-7
DOIs	https://doi.org/10.1007/978-3-540-73922-7_20
Publikationsstatus	Veröffentlicht - 2007
Veranstaltung	6th International Conference on Artificial Immune Systems - Santos, Brasilien Dauer: 26.08.2007 → 29.08.2007 Konferenznummer: 70790

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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Textor, J., & Westermann, J. (2007). Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis. in L. Nunes de Castro, F. José Von Zuben, & H. Knidel (Hrsg.), ICARIS 2007: Artificial Immune Systems (Band 4628 LNCS, S. 228-239). (Lecture Notes in Computer Science; Band 4628 LNCS). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-540-73922-7_20

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title = "Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis",

abstract = "The migration of lymphocytes through secondary lymphoid organs was believed to be mainly controlled by chemokine gradients. This theory has recently been called into question since naive lymphocytes observed in vivo by two-photon microscopy show no evidence of directed migration. We have constructed a simple mathematical model of naive T cell migration in lymph nodes that is solely based on local mechanisms. The model was validated against findings from histological analysis and experimentally determined lymphocyte recirculation kinetics. Our results suggest that T cell compartmentalization in lymph nodes can be explained without long-range chemokine gradients. However, the T cell residence time predicted by our model is significantly lower than observed in vivo, indicating the existence of a mechanism which alters the T cell random walk over time.",

author = "Johannes Textor and J{\"u}rgen Westermann",

year = "2007",

doi = "10.1007/978-3-540-73922-7_20",

language = "English",

isbn = "978-3-540-73921-0",

volume = "4628 LNCS",

series = "Lecture Notes in Computer Science",

publisher = "Springer-Verlag Berlin Heidelberg",

pages = "228--239",

editor = "{Nunes de Castro}, {Leandro } and {Jos{\'e} Von Zuben}, {Fernando } and Knidel, {Helder }",

booktitle = "ICARIS 2007: Artificial Immune Systems",

}

Textor, J & Westermann, J 2007, Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis. in L Nunes de Castro, F José Von Zuben & H Knidel (Hrsg.), ICARIS 2007: Artificial Immune Systems. Bd. 4628 LNCS, Lecture Notes in Computer Science, Bd. 4628 LNCS, Springer-Verlag Berlin Heidelberg, S. 228-239, 6th International Conference on Artificial Immune Systems , Santos, Brasilien, 26.08.07. https://doi.org/10.1007/978-3-540-73922-7_20

Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis. / Textor, Johannes; Westermann, Jürgen.
ICARIS 2007: Artificial Immune Systems. Hrsg. / Leandro Nunes de Castro; Fernando José Von Zuben; Helder Knidel. Band 4628 LNCS Springer-Verlag Berlin Heidelberg, 2007. S. 228-239 (Lecture Notes in Computer Science; Band 4628 LNCS).

Publikation: Kapitel in Büchern/Berichten/Konferenzbänden › Konferenzbeitrag › Begutachtung

TY - GEN

T1 - Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis

AU - Textor, Johannes

AU - Westermann, Jürgen

N1 - Conference code: 70790

PY - 2007

Y1 - 2007

N2 - The migration of lymphocytes through secondary lymphoid organs was believed to be mainly controlled by chemokine gradients. This theory has recently been called into question since naive lymphocytes observed in vivo by two-photon microscopy show no evidence of directed migration. We have constructed a simple mathematical model of naive T cell migration in lymph nodes that is solely based on local mechanisms. The model was validated against findings from histological analysis and experimentally determined lymphocyte recirculation kinetics. Our results suggest that T cell compartmentalization in lymph nodes can be explained without long-range chemokine gradients. However, the T cell residence time predicted by our model is significantly lower than observed in vivo, indicating the existence of a mechanism which alters the T cell random walk over time.

AB - The migration of lymphocytes through secondary lymphoid organs was believed to be mainly controlled by chemokine gradients. This theory has recently been called into question since naive lymphocytes observed in vivo by two-photon microscopy show no evidence of directed migration. We have constructed a simple mathematical model of naive T cell migration in lymph nodes that is solely based on local mechanisms. The model was validated against findings from histological analysis and experimentally determined lymphocyte recirculation kinetics. Our results suggest that T cell compartmentalization in lymph nodes can be explained without long-range chemokine gradients. However, the T cell residence time predicted by our model is significantly lower than observed in vivo, indicating the existence of a mechanism which alters the T cell random walk over time.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-38149142384&origin=inward&txGid=f06abf012104f3fe53d37312556c5202

U2 - 10.1007/978-3-540-73922-7_20

DO - 10.1007/978-3-540-73922-7_20

M3 - Conference contribution

SN - 978-3-540-73921-0

VL - 4628 LNCS

T3 - Lecture Notes in Computer Science

SP - 228

EP - 239

BT - ICARIS 2007: Artificial Immune Systems

A2 - Nunes de Castro, Leandro

A2 - José Von Zuben, Fernando

A2 - Knidel, Helder

PB - Springer-Verlag Berlin Heidelberg

T2 - 6th International Conference on Artificial Immune Systems

Y2 - 26 August 2007 through 29 August 2007

ER -

Modeling migration, compartmentalization and exit of naive T cells in lymph nodes without chemotaxis

Abstract

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