Model-based analysis and optimization of pressure-controlled ventilation of COPD patients in relation to BMI Model-based optimization of pressure-controlled ventilation of COPD patients

This article presents an approach for model-based and personalized determination of inspiratory pressure and inspiratory time in pressure-controlled ventilation. Lung mechanics are strongly dependent on weight and affected by lung diseases such as COPD. Based on a simplified model of the lung with weight- and COPD-specific parameter selection and consideration of ventilation guidelines, the appropriate inspiratory pressure values are calculated. The results illustrate the effect of BMI on the computed optimal pressure-volume ratio. The findings provide a first step towards individualized decision support systems taking into account additional effects like BMI and specific lung diseases.