Many faces of drebrin: From building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes

Irina Majoul; Tomoaki Shirao; Yuko Sekino; Rainer Duden

doi:10.1007/s00418-007-0273-y

Many faces of drebrin: From building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes

Irina Majoul^*, Tomoaki Shirao, Yuko Sekino, Rainer Duden

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biologie

40 Zitate (Scopus)

Abstract

In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein, in the formation of cellular polarity in different cell types. Drebrin has a well-established role in the morphogenesis, patterning and maintenance of dendritic spines in neurons. We have recently shown that drebrin also stabilizes Connexin-43 containing gap junctions at the plasma membrane. The latest literature and our own data suggest that drebrin may be broadly involved in shaping cell processes and in the formation of stabilized plasma membrane domains, an effect that is likely to be of crucial significance for formation of cell polarity in both neuronal and non-neuronal types.

Originalsprache	Englisch
Zeitschrift	Histochemistry and Cell Biology
Jahrgang	127
Ausgabenummer	4
Seiten (von - bis)	355-361
Seitenumfang	7
ISSN	0948-6143
DOIs	https://doi.org/10.1007/s00418-007-0273-y
Publikationsstatus	Veröffentlicht - 04.2007

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Acknowledgments The authors are grateful to Drs. Eugenia Butkevich and Piotr Bregestovski for critical reading of early versions of this manuscript. We thank Dr. Robin Battye (Quorum Technologies; http://www.quorumtechnologies.com/) for his invaluable help with long-time imaging of cells expressing dre-brin, at the “3D Microscopy of Living Cells” course held in 2006 at the University of British Columbia, Vancouver, Canada (http:/ /www.3dcourse.ubc.ca/index.htm). This work was supported by the Wellcome Trust (Senior Fellowship to R.D.; grant number 047578).

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10.1007/s00418-007-0273-y

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title = "Many faces of drebrin: From building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes",

abstract = "In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein, in the formation of cellular polarity in different cell types. Drebrin has a well-established role in the morphogenesis, patterning and maintenance of dendritic spines in neurons. We have recently shown that drebrin also stabilizes Connexin-43 containing gap junctions at the plasma membrane. The latest literature and our own data suggest that drebrin may be broadly involved in shaping cell processes and in the formation of stabilized plasma membrane domains, an effect that is likely to be of crucial significance for formation of cell polarity in both neuronal and non-neuronal types.",

author = "Irina Majoul and Tomoaki Shirao and Yuko Sekino and Rainer Duden",

note = "Funding Information: Acknowledgments The authors are grateful to Drs. Eugenia Butkevich and Piotr Bregestovski for critical reading of early versions of this manuscript. We thank Dr. Robin Battye (Quorum Technologies; http://www.quorumtechnologies.com/) for his invaluable help with long-time imaging of cells expressing dre-brin, at the “3D Microscopy of Living Cells” course held in 2006 at the University of British Columbia, Vancouver, Canada (http:/ /www.3dcourse.ubc.ca/index.htm). This work was supported by the Wellcome Trust (Senior Fellowship to R.D.; grant number 047578). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

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doi = "10.1007/s00418-007-0273-y",

language = "English",

volume = "127",

pages = "355--361",

journal = "Histochemistry and Cell Biology",

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AU - Majoul, Irina

AU - Shirao, Tomoaki

AU - Sekino, Yuko

AU - Duden, Rainer

N1 - Funding Information: Acknowledgments The authors are grateful to Drs. Eugenia Butkevich and Piotr Bregestovski for critical reading of early versions of this manuscript. We thank Dr. Robin Battye (Quorum Technologies; http://www.quorumtechnologies.com/) for his invaluable help with long-time imaging of cells expressing dre-brin, at the “3D Microscopy of Living Cells” course held in 2006 at the University of British Columbia, Vancouver, Canada (http:/ /www.3dcourse.ubc.ca/index.htm). This work was supported by the Wellcome Trust (Senior Fellowship to R.D.; grant number 047578). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/4

Y1 - 2007/4

N2 - In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein, in the formation of cellular polarity in different cell types. Drebrin has a well-established role in the morphogenesis, patterning and maintenance of dendritic spines in neurons. We have recently shown that drebrin also stabilizes Connexin-43 containing gap junctions at the plasma membrane. The latest literature and our own data suggest that drebrin may be broadly involved in shaping cell processes and in the formation of stabilized plasma membrane domains, an effect that is likely to be of crucial significance for formation of cell polarity in both neuronal and non-neuronal types.

AB - In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein, in the formation of cellular polarity in different cell types. Drebrin has a well-established role in the morphogenesis, patterning and maintenance of dendritic spines in neurons. We have recently shown that drebrin also stabilizes Connexin-43 containing gap junctions at the plasma membrane. The latest literature and our own data suggest that drebrin may be broadly involved in shaping cell processes and in the formation of stabilized plasma membrane domains, an effect that is likely to be of crucial significance for formation of cell polarity in both neuronal and non-neuronal types.

UR - https://www.scopus.com/pages/publications/33847696641

U2 - 10.1007/s00418-007-0273-y

DO - 10.1007/s00418-007-0273-y

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SP - 355

EP - 361

JO - Histochemistry and Cell Biology

JF - Histochemistry and Cell Biology

IS - 4

ER -

Many faces of drebrin: From building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes

Abstract

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Strategische Forschungsbereiche und Zentren

Dokumente

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