Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: Macrophage-mediated neutrophil infiltration depends on mast cell activation

Ruoyan Chen, Janet A. Fairley, Ming Lang Zhao, George J. Giudice, Detlef Zillikens, Luis A. Diaz, Zhi Liu*

*Korrespondierende/r Autor/-in für diese Arbeit
84 Zitate (Scopus)

Abstract

Bullous pemphigoid (BP) is a subepidermal blistering disease associated with autoantibodies against two hemidesmosomal proteins, BP180 and BP230. Numerous inflammatory cells infiltrate the upper dermis in BP. We have previously shown by passive transfer studies that Abs to the ectodomain of murine BP180 are capable of triggering blisters in mice that closely mimic human BP. Experimental BP depends on complement activation and neutrophil infiltration. In the present study, we investigated the relative contribution of neutrophils, mast cells (MCs), macrophages (Mφ), and lymphocytes and their functional relationship in the immunopathogenesis of this disease model by using mice deficient in these cells. Wild-type, T cell-deficient, and T and B cell-deficient mice injected intradermally with pathogenic anti-murine BP180 IgG exhibited extensive subepidermal blisters. In contrast, mice deficient in neutrophils, MCs, and Mφ were resistant to experimental BP. MCs play a major role in neutrophil recruitment into the dermis. Furthermore, Mφ-mediated neutrophil infiltration depends on MC activation/degranulation.

OriginalspracheEnglisch
ZeitschriftJournal of Immunology
Jahrgang169
Ausgabenummer7
Seiten (von - bis)3987-3992
Seitenumfang6
ISSN0022-1767
DOIs
PublikationsstatusVeröffentlicht - 01.10.2002

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