TY - JOUR
T1 - Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components
AU - Janzer, Andreas
AU - Lim, Soyoung
AU - Fronhoffs, Florian
AU - Niazy, Naima
AU - Buettner, Reinhard
AU - Kirfel, Jutta
N1 - Funding Information:
This work was supported by grants from the DFG and the German Cancer Aid to RB and JK.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/5/18
Y1 - 2012/5/18
N2 - Histone modifying enzymes confer epigenetic marks, directing the changes in gene expression required for diverse cellular processes. Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9. Analyzing transcriptomes on microarrays, we identified genes which represent inflammatory-related targets of LSD1. We demonstrate a repressive role of LSD1 in proinflammatory cytokine expression such as IL1α, IL1β, IL6 and IL8 and classical complement components. Consistently, LSD1 occupies and regulates the promoter of these genes. In addition, we demonstrate that HDAC1 and LSD1 synergistically regulate these inflammatory-related genes. Our data reveal a novel role for LSD1 in suppressing immune responses.
AB - Histone modifying enzymes confer epigenetic marks, directing the changes in gene expression required for diverse cellular processes. Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9. Analyzing transcriptomes on microarrays, we identified genes which represent inflammatory-related targets of LSD1. We demonstrate a repressive role of LSD1 in proinflammatory cytokine expression such as IL1α, IL1β, IL6 and IL8 and classical complement components. Consistently, LSD1 occupies and regulates the promoter of these genes. In addition, we demonstrate that HDAC1 and LSD1 synergistically regulate these inflammatory-related genes. Our data reveal a novel role for LSD1 in suppressing immune responses.
UR - http://www.scopus.com/inward/record.url?scp=84861221167&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2012.04.057
DO - 10.1016/j.bbrc.2012.04.057
M3 - Journal articles
C2 - 22542627
AN - SCOPUS:84861221167
SN - 0006-291X
VL - 421
SP - 665
EP - 670
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -
