Low-dose methotrexate in rheumatic diseases-Efficacy, side effects, and risk factors for side effects

Armin Schnabel, Wolfgang L. Gross

114 Zitate (Scopus)

Abstract

Controlled trials and observational studies have shown low-dose methotrexate (MTX) to be a second-line agent of high potency with a favorable profile of safety and tolerability in the treatment of rheumatoid arthritis (RA). Its riskbenefit ratio in psoriatic arthritis is less well documented. Preliminary reports on its beneficial effects in other disorders, including the systemic manifestations of RA, other spondyloarthritides, and collagen vascular diseases, merit more detailed examination. Gastrointestinal intolerance and hepatic enzyme elevation are the most frequent side effects of MTX; life-threatening events such as severe hemocytopenia and MTX pneumonitis are rare and amenable to prevention by recognizing risk factors and premonitory signs. Hepatotoxicity does not appear to be a major limiting factor in RA patients over the first 2 to 3 years of MTX therapy; its impact on long-term tolerance remains to be clarified.

OriginalspracheEnglisch
ZeitschriftSeminars in Arthritis and Rheumatism
Jahrgang23
Ausgabenummer5
Seiten (von - bis)310-327
Seitenumfang18
ISSN0049-0172
DOIs
PublikationsstatusVeröffentlicht - 04.1994

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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