Localized linear IgA disease induced by ampicillin/sulbactam

Iakov Shimanovich; Christian Rose; Cassian Sitaru; Eva B. Bröcker; Detlef Zillikens

doi:10.1016/j.jaad.2004.03.027

Localized linear IgA disease induced by ampicillin/sulbactam

Iakov Shimanovich, Christian Rose, Cassian Sitaru, Eva B. Bröcker, Detlef Zillikens^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Dermatologie, Allergologie und Venerologie

Julius-Maximilians-Universität Würzburg

26 Zitate (Scopus)

Abstract

We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

Originalsprache	Englisch
Zeitschrift	Journal of the American Academy of Dermatology
Jahrgang	51
Ausgabenummer	1
Seiten (von - bis)	95-98
Seitenumfang	4
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2004.03.027
Publikationsstatus	Veröffentlicht - 07.2004

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title = "Localized linear IgA disease induced by ampicillin/sulbactam",

abstract = "We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.",

author = "Iakov Shimanovich and Christian Rose and Cassian Sitaru and Br{\"o}cker, {Eva B.} and Detlef Zillikens",

note = "Funding Information: Supported by grant 98.073.2 from the Wilhelm Sander-Stiftung, Munich, Germany. ",

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AU - Shimanovich, Iakov

AU - Rose, Christian

AU - Sitaru, Cassian

AU - Bröcker, Eva B.

AU - Zillikens, Detlef

N1 - Funding Information: Supported by grant 98.073.2 from the Wilhelm Sander-Stiftung, Munich, Germany.

PY - 2004/7

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N2 - We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

AB - We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

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M3 - Journal articles

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AN - SCOPUS:3042737603

SN - 0190-9622

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SP - 95

EP - 98

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

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Localized linear IgA disease induced by ampicillin/sulbactam

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