Laterality judgements in patients with frequent episodic migraine

Introduction: Migraine is a cyclic disorder but also a chronic pain condition. Left-right recognition tasks have been shown to be impaired in patients with chronic pain. Objectives: To investigate whether laterality judgements of migraine patients depend on the status within the migraine cycle. Methods: 34 episodic migraine patients completed a laterality recognition task on 30 consecutive days using the Recognise™ software. Reaction time and number of mistakes of recognising the left or right side of a face or neck movements to the right or left were recorded and analysed longitudinally. Ictal days (48 h and 24 h prior to the attack; during the headache phase; 24 h after the attack) were contrasted against interictal days using repeated measures ANOVAs. 4 headache-free controls served to investigate the natural fluctuation over time and to compare migraine versus non-migraine data in a secondary exploratory analysis. Results: 1691 data sets from migraine patients and 183 from control participants were included in the analyses. Results indicated that performance varied throughout the migraine cycle but only showed a clear pattern of prolonged response times for images of movements to the right (F(4,1690) = 2.412; p = 0.047), while data for frequency of correct answers and for the left side remained inconclusive. Migraine patients had a reduced frequency of correct answers (right: F(1,1873) = 11.426; p = 0.001; left: F(1,1873) = 5.873; p = 0.015). Response times where unaffected. Laterality judgements were not correlated with the dominant headache side. Conclusions: The current data shows that laterality judgements can depend on the status within the migraine cycle. Laterality judgements of migraine patients where comparable to other chronic pain conditions.