Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Bernd Schultes; Sebastian M. Schmid; Britta Wilms; Kamila Jauch-Chara; Kerstin M. Oltmanns; Manfred Hallschmid

doi:10.1016/j.appet.2012.01.022

Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Bernd Schultes^*, Sebastian M. Schmid, Britta Wilms, Kamila Jauch-Chara, Kerstin M. Oltmanns, Manfred Hallschmid

^*Korrespondierende/r Autor/-in für diese Arbeit

25 Zitate (Scopus)

Abstract

Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m²) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

Originalsprache	Englisch
Zeitschrift	Appetite
Jahrgang	58
Ausgabenummer	3
Seiten (von - bis)	818-821
Seitenumfang	4
ISSN	0195-6663
DOIs	https://doi.org/10.1016/j.appet.2012.01.022
Publikationsstatus	Veröffentlicht - 01.06.2012

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10.1016/j.appet.2012.01.022

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title = "Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men",

abstract = "Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.",

author = "Bernd Schultes and Schmid, \{Sebastian M.\} and Britta Wilms and Kamila Jauch-Chara and Oltmanns, \{Kerstin M.\} and Manfred Hallschmid",

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T1 - Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

AU - Schultes, Bernd

AU - Schmid, Sebastian M.

AU - Wilms, Britta

AU - Jauch-Chara, Kamila

AU - Oltmanns, Kerstin M.

AU - Hallschmid, Manfred

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

AB - Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

UR - https://www.scopus.com/pages/publications/84857580283

U2 - 10.1016/j.appet.2012.01.022

DO - 10.1016/j.appet.2012.01.022

M3 - Journal articles

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AN - SCOPUS:84857580283

SN - 0195-6663

VL - 58

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JO - Appetite

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ER -

Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Abstract

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