Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

Daphne Shimron-Abarbanell; Markus M. Nöthen; Jeanette Erdmann; Peter Propping

doi:10.1016/0169-328X(95)00003-B

Lack of genetically determined structural variants of the human serotonin-1E (5-HT_1E) receptor protein points to its evolutionary conservation

Daphne Shimron-Abarbanell, Markus M. Nöthen^*, Jeanette Erdmann, Peter Propping

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Kardiogenetik

Rheinische Friedrich-Wilhelms-Universität Bonn

25 Zitate (Scopus)

Abstract

Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT_1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT_1E receptor protein points to a high evolutionary conservation of this receptor protein.

Originalsprache	Englisch
Zeitschrift	Molecular Brain Research
Jahrgang	29
Ausgabenummer	2
Seiten (von - bis)	387-390
Seitenumfang	4
ISSN	0169-328X
DOIs	https://doi.org/10.1016/0169-328X(95)00003-B
Publikationsstatus	Veröffentlicht - 01.01.1995

Fördermittel

This work was supported by the Deutsche Forschungsgemeinschaft. We thank Dres. M. Ri-etschel, J. K6rner, J. Hebebrand, K. Hebebrand, R. Wettke-Sch~ifer, S. Lisch, A. von Gontard, G. Lehmkuhl, M. Schmidt, F. Poustka and H. Rem-schmidt for contribution of patients to the study.

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10.1016/0169-328X(95)00003-B

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title = "Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation",

abstract = "Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.",

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Lack of genetically determined structural variants of the human serotonin-1E (5-HT_1E) receptor protein points to its evolutionary conservation. / Shimron-Abarbanell, Daphne; Nöthen, Markus M.; Erdmann, Jeanette et al.
in: Molecular Brain Research, Jahrgang 29, Nr. 2, 01.01.1995, S. 387-390.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

AU - Shimron-Abarbanell, Daphne

AU - Nöthen, Markus M.

AU - Erdmann, Jeanette

AU - Propping, Peter

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.

AB - Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.

UR - https://www.scopus.com/pages/publications/0028937303

U2 - 10.1016/0169-328X(95)00003-B

DO - 10.1016/0169-328X(95)00003-B

M3 - Journal articles

C2 - 7609628

AN - SCOPUS:0028937303

SN - 0169-328X

VL - 29

SP - 387

EP - 390

JO - Molecular Brain Research

JF - Molecular Brain Research

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