TY - JOUR
T1 - Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation
AU - Shimron-Abarbanell, Daphne
AU - Nöthen, Markus M.
AU - Erdmann, Jeanette
AU - Propping, Peter
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.
AB - Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.
UR - http://www.scopus.com/inward/record.url?scp=0028937303&partnerID=8YFLogxK
U2 - 10.1016/0169-328X(95)00003-B
DO - 10.1016/0169-328X(95)00003-B
M3 - Journal articles
C2 - 7609628
AN - SCOPUS:0028937303
SN - 0169-328X
VL - 29
SP - 387
EP - 390
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -