Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

Daphne Shimron-Abarbanell, Markus M. Nöthen*, Jeanette Erdmann, Peter Propping

*Korrespondierende/r Autor/-in für diese Arbeit
19 Zitate (Scopus)

Abstract

Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.
OriginalspracheEnglisch
ZeitschriftMolecular Brain Research
Jahrgang29
Ausgabenummer2
Seiten (von - bis)387-390
Seitenumfang4
ISSN0169-328X
DOIs
PublikationsstatusVeröffentlicht - 01.01.1995

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