Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

Wolfgang Lieb; Tanja Zeller; Massimo Mangino; Anika Götz; Peter Braund; Juergen J. Wenzel; Christian Horn; Carole Proust; Patrick Linsel-Nitschke; Philippe Amouyel; Petra Bruse; Dominique Arveiler; Inke R. König; Jean Ferrières; Andreas Ziegler; Anthony J. Balmforth; Alun Evans; Pierre Ducimetière; Francois Cambien; Christian Hengstenberg; Klaus Stark; Alistair S. Hall; Heribert Schunkert; Stefan Blankenberg; Nilesh J. Samani; Jeanette Erdmann; Laurence Tiret

doi:10.1007/s00109-008-0376-5

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

Wolfgang Lieb, Tanja Zeller, Massimo Mangino, Anika Götz, Peter Braund, Juergen J. Wenzel, Christian Horn, Carole Proust, Patrick Linsel-Nitschke, Philippe Amouyel, Petra Bruse, Dominique Arveiler, Inke R. König, Jean Ferrières, Andreas Ziegler, Anthony J. Balmforth, Alun Evans, Pierre Ducimetière, Francois Cambien, Christian HengstenbergKlaus Stark, Alistair S. Hall, Heribert Schunkert, Stefan Blankenberg, Nilesh J. Samani, Jeanette Erdmann^*, Laurence Tiret

^*Korrespondierende/r Autor/-in für diese Arbeit

4 Zitate (Scopus)

Abstract

Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.

Originalsprache	Englisch
Zeitschrift	Journal of Molecular Medicine
Jahrgang	86
Ausgabenummer	10
Seiten (von - bis)	1163-1170
Seitenumfang	8
ISSN	0946-2716
DOIs	https://doi.org/10.1007/s00109-008-0376-5
Publikationsstatus	Veröffentlicht - 01.10.2008

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Lieb, W., Zeller, T., Mangino, M., Götz, A., Braund, P., Wenzel, J. J., Horn, C., Proust, C., Linsel-Nitschke, P., Amouyel, P., Bruse, P., Arveiler, D., König, I. R., Ferrières, J., Ziegler, A., Balmforth, A. J., Evans, A., Ducimetière, P., Cambien, F., ... Tiret, L. (2008). Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. Journal of Molecular Medicine, 86(10), 1163-1170. https://doi.org/10.1007/s00109-008-0376-5

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title = "Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction",

abstract = "Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.",

author = "Wolfgang Lieb and Tanja Zeller and Massimo Mangino and Anika G{\"o}tz and Peter Braund and Wenzel, {Juergen J.} and Christian Horn and Carole Proust and Patrick Linsel-Nitschke and Philippe Amouyel and Petra Bruse and Dominique Arveiler and K{\"o}nig, {Inke R.} and Jean Ferri{\`e}res and Andreas Ziegler and Balmforth, {Anthony J.} and Alun Evans and Pierre Ducimeti{\`e}re and Francois Cambien and Christian Hengstenberg and Klaus Stark and Hall, {Alistair S.} and Heribert Schunkert and Stefan Blankenberg and Samani, {Nilesh J.} and Jeanette Erdmann and Laurence Tiret",

year = "2008",

month = oct,

day = "1",

doi = "10.1007/s00109-008-0376-5",

language = "English",

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pages = "1163--1170",

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Lieb, W, Zeller, T, Mangino, M, Götz, A, Braund, P, Wenzel, JJ, Horn, C, Proust, C, Linsel-Nitschke, P, Amouyel, P, Bruse, P, Arveiler, D, König, IR, Ferrières, J, Ziegler, A, Balmforth, AJ, Evans, A, Ducimetière, P, Cambien, F, Hengstenberg, C, Stark, K, Hall, AS, Schunkert, H, Blankenberg, S, Samani, NJ, Erdmann, J & Tiret, L 2008, 'Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction', Journal of Molecular Medicine, Jg. 86, Nr. 10, S. 1163-1170. https://doi.org/10.1007/s00109-008-0376-5

TY - JOUR

T1 - Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

AU - Lieb, Wolfgang

AU - Zeller, Tanja

AU - Mangino, Massimo

AU - Götz, Anika

AU - Braund, Peter

AU - Wenzel, Juergen J.

AU - Horn, Christian

AU - Proust, Carole

AU - Linsel-Nitschke, Patrick

AU - Amouyel, Philippe

AU - Bruse, Petra

AU - Arveiler, Dominique

AU - König, Inke R.

AU - Ferrières, Jean

AU - Ziegler, Andreas

AU - Balmforth, Anthony J.

AU - Evans, Alun

AU - Ducimetière, Pierre

AU - Cambien, Francois

AU - Hengstenberg, Christian

AU - Stark, Klaus

AU - Hall, Alistair S.

AU - Schunkert, Heribert

AU - Blankenberg, Stefan

AU - Samani, Nilesh J.

AU - Erdmann, Jeanette

AU - Tiret, Laurence

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.

AB - Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.

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U2 - 10.1007/s00109-008-0376-5

DO - 10.1007/s00109-008-0376-5

M3 - Journal articles

C2 - 18592168

AN - SCOPUS:52549088057

SN - 0946-2716

VL - 86

SP - 1163

EP - 1170

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

IS - 10

ER -

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

Abstract

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