Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

M M Nöthen; J Erdmann; J Körner; M Lanczik; J Fritze; R Fimmers; D K Grandy; B O'Dowd; P Propping

doi:10.1176/ajp.149.2.199

Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

M M Nöthen, J Erdmann, J Körner, M Lanczik, J Fritze, R Fimmers, D K Grandy, B O'Dowd, P Propping

Institut für Kardiogenetik

Rheinische Friedrich-Wilhelms-Universität Bonn

Abstract

Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

Originalsprache	Englisch
Zeitschrift	The American journal of psychiatry
Jahrgang	149
Ausgabenummer	2
Seiten (von - bis)	199-201
Seitenumfang	3
ISSN	0002-953X
DOIs	https://doi.org/10.1176/ajp.149.2.199
Publikationsstatus	Veröffentlicht - 02.1992

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10.1176/ajp.149.2.199

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abstract = "Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.",

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AU - Erdmann, J

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AU - Fritze, J

AU - Fimmers, R

AU - Grandy, D K

AU - O'Dowd, B

AU - Propping, P

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AB - Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

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DO - 10.1176/ajp.149.2.199

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