Lässt sich die Expression von EZM-Proteinen durch Kompression beeinflussen?

Okka Gerdes*, J. Brinckmann, D. Zillikens, B. Kahle

*Korrespondierende/r Autor/-in für diese Arbeit
1 Zitat (Scopus)

Abstract

Background: The advanced states of the chronic venous insufficiency (CVI) are characterized by an increased protein expression of tenascin C, fibrillin 2 and α-smooth muscle actin. These proteins of the extracellular maktrix are augmentedly expressed during wound healing in hypertrophy scars. Objective: Is the expression of the proteins tenascin C, fibrillin2 und α-smooth muscle actin suggestible by compression? Patient and Methods: We investigated the skin of 23 patients (12 in state C2 and 11 in state C4). These patients were not treated with compression therapy before. They got compression stockings for 2 or 4 weeks (VenoTrain delight or VenoTrain micro). On day 1, 14 and 28 we took a skin sample from the ankle.Results: In stadium C2 of the CVI there was an expression as in normal skin, a small band belong the dermal-epidermal junction and in blood vessels. In stadium C4 the expression varied corresponding to the clinical figure. In lipodermatosclerosis, tenascin C and fibrillin 2 were increasingly expressed in the whole dermis. On hyperpigmentation or in stasis dermatitis there was an increased expression just in a few biopsies. In some cases the augmented expression was present in the deeper dermis, in other cases in the dermal-epidermal junction. α-smooth muscle actin was expressed in both stadium C2 and C4 only in blood vessels. Druing the study an effect of compression therapy on protein expression was not obvious. Conclusion: Tenascin C and fibrillin 2 were only expressed in the state of a sclerosis. The influence of compression on the expression of extracellular matrix proteins needs further investigations.
Titel in ÜbersetzungInfluence of compression therapy on expression of extracellular matrix proteins in chronic venous insufficiency of the lower leg
OriginalspracheDeutsch
ZeitschriftPhlebologie
Jahrgang41
Ausgabenummer3
Seiten (von - bis)121-127
Seitenumfang7
ISSN0939-978X
PublikationsstatusVeröffentlicht - 13.09.2012

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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