Abstract
Background: The advanced states of the chronic venous insufficiency (CVI) are characterized by an increased protein expression of tenascin C, fibrillin 2 and α-smooth muscle actin. These proteins of the extracellular maktrix are augmentedly expressed during wound healing in hypertrophy scars. Objective: Is the expression of the proteins tenascin C, fibrillin2 und α-smooth muscle actin suggestible by compression? Patient and Methods: We investigated the skin of 23 patients (12 in state C2 and 11 in state C4). These patients were not treated with compression therapy before. They got compression stockings for 2 or 4 weeks (VenoTrain delight or VenoTrain micro). On day 1, 14 and 28 we took a skin sample from the ankle.Results: In stadium C2 of the CVI there was an expression as in normal skin, a small band belong the dermal-epidermal junction and in blood vessels. In stadium C4 the expression varied corresponding to the clinical figure. In lipodermatosclerosis, tenascin C and fibrillin 2 were increasingly expressed in the whole dermis. On hyperpigmentation or in stasis dermatitis there was an increased expression just in a few biopsies. In some cases the augmented expression was present in the deeper dermis, in other cases in the dermal-epidermal junction. α-smooth muscle actin was expressed in both stadium C2 and C4 only in blood vessels. Druing the study an effect of compression therapy on protein expression was not obvious. Conclusion: Tenascin C and fibrillin 2 were only expressed in the state of a sclerosis. The influence of compression on the expression of extracellular matrix proteins needs further investigations.
Titel in Übersetzung | Influence of compression therapy on expression of extracellular matrix proteins in chronic venous insufficiency of the lower leg |
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Originalsprache | Deutsch |
Zeitschrift | Phlebologie |
Jahrgang | 41 |
Ausgabenummer | 3 |
Seiten (von - bis) | 121-127 |
Seitenumfang | 7 |
ISSN | 0939-978X |
Publikationsstatus | Veröffentlicht - 13.09.2012 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)