Is a model useful in exploring the catabolic mechanisms of weight loss after gastric bypass in humans?

Henriette Kirchner, Ana Guijarro, Michael M. Meguid*

*Korrespondierende/r Autor/-in für diese Arbeit
11 Zitate (Scopus)

Abstract

PURPOSE OF REVIEW: In the USA, approximately 3% of adults are morbidly obese, in whom behavior modification and drug therapy is ineffective in inducing major weight loss. Surgery is their only reliable option. The Roux-en-Y gastric bypass accounts for 90% of all bariatric surgeries because it achieves the best weight loss results. Many studies describe weight loss and changes in metabolic blood parameters after Roux-en-Y gastric bypass. We compare recent human data with the findings in our rats to validate the versatility of using a Roux-en-Y gastric bypass rat model to explore the multifactorial molecular and physiological dimensions of weight loss and weight regain. RECENT FINDINGS: Not only mechanical factors but also changes in gastrointestinal and adipose hormones and hypothalamic neuropeptides contribute to Roux-en-Y gastric bypass induced weight loss by promoting catabolic processes. Nevertheless, the exact mechanisms of weight loss remain unknown. SUMMARY: To investigate these catabolic mechanisms we used our Roux-en-Y gastric bypass rat model in diet induced obese rats. We found clear morphometric, physiological and biochemical parallelisms between humans and our rats. It is likely that Roux-en-Y gastric bypass induces similar changes in hypothalamic neuropeptides which can only be studied using the rat model. It therefore provides a useful research tool for exploring and studying the development of adjuvant antiobesity therapies.

OriginalspracheEnglisch
ZeitschriftCurrent Opinion in Clinical Nutrition and Metabolic Care
Jahrgang10
Ausgabenummer4
Seiten (von - bis)463-474
Seitenumfang12
ISSN1363-1950
DOIs
PublikationsstatusVeröffentlicht - 01.07.2007

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