Interplay between environmentally modulated feedback loops – hypoxia and circadian rhythms – two sides of the same coin?

Reinhard Depping; Henrik Oster

doi:10.1111/febs.14306

Interplay between environmentally modulated feedback loops – hypoxia and circadian rhythms – two sides of the same coin?

Abstract

Sensing of environmental parameters is critically important for cells of metazoan organisms. Members of the superfamily of bHLH‐PAS transcription factors, involved in oxygen sensing and circadian rhythm generation, are important players in such molecular pathways. The interplay between both networks includes a so far unknown factor, connecting PER2 (circadian clocks) to hypoxia sensing (HIF‐1 α) to result in a more adapted state of homeostasis at the right time.

Originalsprache	Englisch
Zeitschrift	FEBS Journal
Jahrgang	284
Ausgabenummer	22
Seiten (von - bis)	3801-3803
Seitenumfang	3
ISSN	1742-464X
DOIs	https://doi.org/10.1111/febs.14306
Publikationsstatus	Veröffentlicht - 01.11.2017

Fördermittel

The research of author RD′s group is supported by the German Research Foundation (DFG) (KO5512/2-1). HO is supported by the DFG (GRK-1957 and SFB-134) and the Volkswagen Foundation.

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 8 – Angemessene Arbeitsbedingungen und wirtschaftliches Wachstum
SDG 10 – Weniger Ungleichheiten

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Dokumente

10.1111/febs.14306

Weitere Links

Link to publication in Scopus

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@article{f3458ec212f841f0a5d5020ea7d753da,

title = "Interplay between environmentally modulated feedback loops – hypoxia and circadian rhythms – two sides of the same coin?",

abstract = "Sensing of environmental parameters is critically important for cells of metazoan organisms. Members of the superfamily of bHLH‐PAS transcription factors, involved in oxygen sensing and circadian rhythm generation, are important players in such molecular pathways. The interplay between both networks includes a so far unknown factor, connecting PER2 (circadian clocks) to hypoxia sensing (HIF‐1 α) to result in a more adapted state of homeostasis at the right time. ",

author = "Reinhard Depping and Henrik Oster",

year = "2017",

month = nov,

day = "1",

doi = "10.1111/febs.14306",

language = "English",

volume = "284",

pages = "3801--3803",

journal = "FEBS Journal",

issn = "1742-464X",