Interplay between environmentally modulated feedback loops – hypoxia and circadian rhythms – two sides of the same coin?

Abstract

Sensing of environmental parameters is critically important for cells of metazoan organisms. Members of the superfamily of bHLH‐PAS transcription factors, involved in oxygen sensing and circadian rhythm generation, are important players in such molecular pathways. The interplay between both networks includes a so far unknown factor, connecting PER2 (circadian clocks) to hypoxia sensing (HIF‐1 α) to result in a more adapted state of homeostasis at the right time.
OriginalspracheEnglisch
ZeitschriftFEBS Journal
Jahrgang284
Ausgabenummer22
Seiten (von - bis)3801-3803
Seitenumfang3
ISSN1742-464X
DOIs
PublikationsstatusVeröffentlicht - 01.11.2017

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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