International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance

Daniel Rudolf, Nikolay Michaylov, Mark Van Der Linden, Ludwig Hoy, Keith P. Klugman, Tobias Welte, Mathias W. Pletz*

*Korrespondierende/r Autor/-in für diese Arbeit
7 Zitate (Scopus)

Abstract

A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia (CAP) were analyzed. Thirty percent showed a close relationship to international clones and had fitness equal to or exceeding that of other strains (P = 0.015); these factors may result in the endurance of these strains despite a reduction of antibiotic usage.

OriginalspracheEnglisch
ZeitschriftAntimicrobial Agents and Chemotherapy
Jahrgang55
Ausgabenummer10
Seiten (von - bis)4915-4917
Seitenumfang3
ISSN0066-4804
DOIs
PublikationsstatusVeröffentlicht - 01.10.2011

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