Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

W. Göpel; C. Härtel; P. Ahrens; I. König; E. Kattner; E. Kuhls; H. Küster; J. Möller; D. Müller; B. Roth; H. Segerer; C. Wieg; E. Herting

doi:10.1038/sj.gene.6364264

Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

W. Göpel^*, C. Härtel, P. Ahrens, I. König, E. Kattner, E. Kuhls, H. Küster, J. Möller, D. Müller, B. Roth, H. Segerer, C. Wieg, E. Herting

^*Korrespondierende/r Autor/-in für diese Arbeit

50 Zitate (Scopus)

Abstract

We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8%, IL-6-174GC (n = 605) 9% and IL-6-174CC (n = 167) 12% (P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers (n=157), 26% of IL-6-174GC-carriers (n = 193) and 27% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.

Originalsprache	Englisch
Zeitschrift	Genes and Immunity
Jahrgang	7
Ausgabenummer	1
Seiten (von - bis)	65-68
Seitenumfang	4
ISSN	1466-4879
DOIs	https://doi.org/10.1038/sj.gene.6364264
Publikationsstatus	Veröffentlicht - 01.2006

Fördermittel

The authors thank Anja Sewe and Sabine Ziesenitz for excellent laboratory assistance, Birgit Roenspiess and Anne Hoegemann for skillful data collection, all doctors and nurses of the participating hospitals, and especially all infants and their parents for their support. This work was supported by the Deutsche Forschungsge-meinschaft, Grant-no. Go955/1-3.

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Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen
SDG 5 – Gender Equality

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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10.1038/sj.gene.6364264

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@article{f6d814d3c9954772a156b3cd7aa2d56a,

title = "Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants",

abstract = "We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8\%, IL-6-174GC (n = 605) 9\% and IL-6-174CC (n = 167) 12\% (P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19\% of IL-6-174GG-carriers (n=157), 26\% of IL-6-174GC-carriers (n = 193) and 27\% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.",

author = "W. G{\"o}pel and C. H{\"a}rtel and P. Ahrens and I. K{\"o}nig and E. Kattner and E. Kuhls and H. K{\"u}ster and J. M{\"o}ller and D. M{\"u}ller and B. Roth and H. Segerer and C. Wieg and E. Herting",

note = "Funding Information: The authors thank Anja Sewe and Sabine Ziesenitz for excellent laboratory assistance, Birgit Roenspiess and Anne Hoegemann for skillful data collection, all doctors and nurses of the participating hospitals, and especially all infants and their parents for their support. This work was supported by the Deutsche Forschungsge-meinschaft, Grant-no. Go955/1-3. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2006",

month = jan,

doi = "10.1038/sj.gene.6364264",

language = "English",

volume = "7",

pages = "65--68",

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T1 - Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

AU - Göpel, W.

AU - Härtel, C.

AU - Ahrens, P.

AU - König, I.

AU - Kattner, E.

AU - Kuhls, E.

AU - Küster, H.

AU - Möller, J.

AU - Müller, D.

AU - Roth, B.

AU - Segerer, H.

AU - Wieg, C.

AU - Herting, E.

N1 - Funding Information: The authors thank Anja Sewe and Sabine Ziesenitz for excellent laboratory assistance, Birgit Roenspiess and Anne Hoegemann for skillful data collection, all doctors and nurses of the participating hospitals, and especially all infants and their parents for their support. This work was supported by the Deutsche Forschungsge-meinschaft, Grant-no. Go955/1-3. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2006/1

Y1 - 2006/1

N2 - We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8%, IL-6-174GC (n = 605) 9% and IL-6-174CC (n = 167) 12% (P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers (n=157), 26% of IL-6-174GC-carriers (n = 193) and 27% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.

AB - We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8%, IL-6-174GC (n = 605) 9% and IL-6-174CC (n = 167) 12% (P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers (n=157), 26% of IL-6-174GC-carriers (n = 193) and 27% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.

UR - https://www.scopus.com/pages/publications/33645137794

U2 - 10.1038/sj.gene.6364264

DO - 10.1038/sj.gene.6364264

M3 - Journal articles

C2 - 16208404

AN - SCOPUS:33645137794

SN - 1466-4879

VL - 7

SP - 65

EP - 68

JO - Genes and Immunity

JF - Genes and Immunity

IS - 1

ER -

Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

Abstract

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UN SDGs

Strategische Forschungsbereiche und Zentren

Dokumente

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