Insights on auditory closed-loop stimulation targeting sleep spindles in slow oscillation up-states

Hong Viet V. Ngo, Mitja Seibold, Désirée C. Boche, Matthias Mölle, Jan Born*

*Korrespondierende/r Autor/-in für diese Arbeit
17 Zitate (Scopus)

Abstract

Background: The consolidation of sleep-dependent memories is mediated by an interplay of cortical slow oscillations (SOs) and thalamo-cortical sleep spindles. Whereas an enhancement of SOs with auditory closed-loop stimulation has been proven highly successful, the feasibility to induce and boost sleep spindles with auditory stimulation remains unknown thus far. New method: Here we tested the possibility to enhance spindle activity during endogenous SOs and thereby to promote memory consolidation. Performing a sleep study in healthy humans, we applied an auditory Spindle stimulation and compared it with an Arrhythmic stimulation and a control condition comprising no stimulation (Sham). Results: With Spindle stimulation we were not able to directly entrain endogenous spindle activity during SO up-states. Instead, both Spindle and Arrhythmic stimulation evoked a resonant SO response accompanied by an increase in spindle power phase-locked to the SO up-state. Assessment of overnight retention of declarative word-pairs revealed no difference between all conditions. Comparison with existing methods: Our Spindle stimulation produced oscillatory evoked responses (i.e., increases in SOs and spindle activity during SO up-states) quite similar to those observed after the auditory closed-loop stimulation of SOs in previous studies, lacking however the beneficial effects on memory retention. Conclusion: Our findings put the endeavour for a selective enhancement of spindle activity via auditory pathways into perspective and reveal central questions with regard to the stimulation efficacy on both an electrophysiological and a neurobehavioral level.

OriginalspracheEnglisch
ZeitschriftJournal of Neuroscience Methods
Jahrgang316
Seiten (von - bis)117-124
Seitenumfang8
ISSN0165-0270
DOIs
PublikationsstatusVeröffentlicht - 15.03.2019

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

Fingerprint

Untersuchen Sie die Forschungsthemen von „Insights on auditory closed-loop stimulation targeting sleep spindles in slow oscillation up-states“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren