Insights into neuronal cell metabolism using NMR spectroscopy: Uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker

Anika Gallinger; Thorsten Biet; Luc Pellerin; Thomas Peters

doi:10.1002/anie.201104836

Insights into neuronal cell metabolism using NMR spectroscopy: Uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker

Anika Gallinger, Thorsten Biet, Luc Pellerin, Thomas Peters^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Chemie und Metabolomics

University of Lausanne

6 Zitate (Scopus)

Abstract

Making the switch: Compounds 1 and 2 are used as metabolic markers for NMR detection. When neuronal cells switch to a glycolytic state, an uneven distribution of ¹³C in the N-acetyl group results, thus giving a mixture of the metabolites 1 and 2. It is therefore possible to monitor flux through different metabolic pathways, such as glycolysis, the tricarboxylic acid cycle, and the hexosamine biosynthetic pathway, using a single molecule.

Originalsprache	Englisch
Zeitschrift	Angewandte Chemie - International Edition
Jahrgang	50
Ausgabenummer	49
Seiten (von - bis)	11672-11674
Seitenumfang	3
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201104836
Publikationsstatus	Veröffentlicht - 02.12.2011

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title = "Insights into neuronal cell metabolism using NMR spectroscopy: Uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker",

abstract = "Making the switch: Compounds 1 and 2 are used as metabolic markers for NMR detection. When neuronal cells switch to a glycolytic state, an uneven distribution of 13C in the N-acetyl group results, thus giving a mixture of the metabolites 1 and 2. It is therefore possible to monitor flux through different metabolic pathways, such as glycolysis, the tricarboxylic acid cycle, and the hexosamine biosynthetic pathway, using a single molecule.",

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Insights into neuronal cell metabolism using NMR spectroscopy: Uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker. / Gallinger, Anika; Biet, Thorsten; Pellerin, Luc et al.
in: Angewandte Chemie - International Edition, Jahrgang 50, Nr. 49, 02.12.2011, S. 11672-11674.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Insights into neuronal cell metabolism using NMR spectroscopy: Uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker

AU - Gallinger, Anika

AU - Biet, Thorsten

AU - Pellerin, Luc

AU - Peters, Thomas

PY - 2011/12/2

Y1 - 2011/12/2

N2 - Making the switch: Compounds 1 and 2 are used as metabolic markers for NMR detection. When neuronal cells switch to a glycolytic state, an uneven distribution of 13C in the N-acetyl group results, thus giving a mixture of the metabolites 1 and 2. It is therefore possible to monitor flux through different metabolic pathways, such as glycolysis, the tricarboxylic acid cycle, and the hexosamine biosynthetic pathway, using a single molecule.

AB - Making the switch: Compounds 1 and 2 are used as metabolic markers for NMR detection. When neuronal cells switch to a glycolytic state, an uneven distribution of 13C in the N-acetyl group results, thus giving a mixture of the metabolites 1 and 2. It is therefore possible to monitor flux through different metabolic pathways, such as glycolysis, the tricarboxylic acid cycle, and the hexosamine biosynthetic pathway, using a single molecule.

UR - https://www.scopus.com/pages/publications/82455175716

U2 - 10.1002/anie.201104836

DO - 10.1002/anie.201104836

M3 - Journal articles

C2 - 22012807

AN - SCOPUS:82455175716

SN - 1433-7851

VL - 50

SP - 11672

EP - 11674

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 49

ER -

Insights into neuronal cell metabolism using NMR spectroscopy: Uridyl diphosphate N-acetyl-glucosamine as a unique metabolic marker

Abstract

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