Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments

Katharina Herrmann, Christian Flöhr, Jens Stalljohann, Gabriela Apiou-Sbirlea, Jochen Kandulla, Reginald Birngruber, Ralf Brinkmann

Abstract

In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.

OriginalspracheEnglisch
TitelTherapeutic Laser Applications and Laser-Tissue Interactions III
Redakteure/-innenAlfred Vogel
Seitenumfang7
Band6632
Herausgeber (Verlag)Optical Society of America
Erscheinungsdatum13.07.2007
ISBN (Print)978-081946771-3
DOIs
PublikationsstatusVeröffentlicht - 13.07.2007
VeranstaltungEuropean Conference on Biomedical Optics 2007 - Munich, Deutschland
Dauer: 17.06.200717.06.2007
Konferenznummer: 104705

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Biomedizintechnik

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